Exceptional stories of microRNAs

被引：41

作者：

Lee, Heon-Jin ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Dent, Brain Sci & Engn Inst, Dept Oral Microbiol, Taegu 700412, South Korea

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 238卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

miRNA; Dicer; Drosha; siRNA; Ago; SMALL NONCODING RNAS; REGULATORY RNAS; CANCER-DETECTION; MAMMALIAN-CELLS; HOST GENES; C-ELEGANS; DICER; BIOGENESIS; MIRNA; IDENTIFICATION;

D O I：

10.1258/ebm.2012.012251

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that regulate the expression of target genes in eukaryotic cells and have been extensively studied in the past decade. However, recent evidence suggests that miRNAs have additional, important roles and functions other than post-transcriptional regulation through binding at the 30 untranslated regions of their target genes. This review describes newly discovered information about the biogenesis and functions of miRNAs as well as presents different points of view about the miRNA system. Our increasing knowledge of the exceptional stories of miRNAs will offer new insights into these powerful gene regulators from virus and bacteria to animals.

引用

收藏

页码：339 / 343

页数：5

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