共 68 条
Moderate systemic therapeutic hypothermia is insufficient to protect blood-spinal cord barrier in spinal cord injury
被引:1
作者:

Zhou, Rubing
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China
Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China
Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Neurobiol, Beijing, Peoples R China Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China

Li, Junzhao
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China
Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Neurobiol, Beijing, Peoples R China Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China

Wang, Ruideng
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China

Chen, Zhengyang
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China

Zhou, Fang
论文数: 0 引用数: 0
h-index: 0
机构:
Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China
机构:
[1] Peking Univ Third Hosp, Dept Orthoped, Beijing, Peoples R China
[2] Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China
[3] Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Neurobiol, Beijing, Peoples R China
来源:
FRONTIERS IN NEUROLOGY
|
2022年
/
13卷
基金:
中国国家自然科学基金;
关键词:
spinal cord injury;
hypothermia;
blood-spinal cord barrier;
two-photon microscopy;
tight junctions;
TRAUMATIC BRAIN-INJURY;
INFLAMMATORY RESPONSE;
TIGHT JUNCTIONS;
PATHOPHYSIOLOGY;
EXPRESSION;
EXTRAVASATION;
PERMEABILITY;
TEMPERATURE;
DISRUPTION;
MECHANISMS;
D O I:
10.3389/fneur.2022.1041099
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Blood-spinal cord barrier (BSCB) disruption is a pivotal event in spinal cord injury (SCI) that aggravates secondary injury but has no specific treatment. Previous reports have shown that systemic therapeutic hypothermia (TH) can protect the blood-brain barrier after brain injury. To verify whether a similar effect exists on the BSCB after SCI, moderate systemic TH at 32 degrees C was induced for 4 h on the mice with contusion-SCI. In vivo two-photon microscopy was utilized to dynamically monitor the BSCB leakage 1 h after SCI, combined with immunohistochemistry to detect BSCB leakage at 1 and 4 h after SCI. The BSCB leakage was not different between the normothermia (NT) and TH groups at both the in vivo and postmortem levels. The expression of endothelial tight junctions was not significantly different between the NT and TH groups 4 h after SCI, as detected by capillary western blotting. The structural damage of the BSCB was examined with immunofluorescence, but the occurrence of junctional gaps was not changed by TH 4 h after SCI. Our results have shown that moderate systemic TH induced for 4 h does not have a protective effect on the disrupted BSCB in early SCI. This treatment method has a low value and is not recommended for BSCB disruption therapy in early SCI.
引用
收藏
页数:10
相关论文
共 68 条
[1]
Hypothermia for Acute Spinal Cord Injury-A Review
[J].
Ahmad, Faiz U.
;
Wang, Michael Y.
;
Levi, Allan D.
.
WORLD NEUROSURGERY,
2014, 82 (1-2)
:207-214

Ahmad, Faiz U.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA

Wang, Michael Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA

Levi, Allan D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA
[2]
Traumatic spinal cord injury
[J].
Ahuja, Christopher S.
;
Wilson, Jefferson R.
;
Nori, Satoshi
;
Kotter, Mark R. N.
;
Druschel, Claudia
;
Curt, Armin
;
Fehlings, Michael G.
.
NATURE REVIEWS DISEASE PRIMERS,
2017, 3

Ahuja, Christopher S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada

Wilson, Jefferson R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada

论文数: 引用数:
h-index:
机构:

Kotter, Mark R. N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Clin Neurosci, Cambridge, England Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada

Druschel, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Berlin, Ctr Muskuloskeletale Chirurg, Berlin, Germany Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada

Curt, Armin
论文数: 0 引用数: 0
h-index: 0
机构:
Balgrist Univ Hosp, Spinal Cord Injury Ctr, Zurich, Switzerland
Univ Zurich, Ordinarius Paraplegiol, Zurich, Switzerland Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada

Fehlings, Michael G.
论文数: 0 引用数: 0
h-index: 0
机构:
Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada Toronto Western Hosp, West Wing 4th Floor,399 Bathurst St, Toronto, ON M5T 2S8, Canada
[3]
Traumatic Spinal Cord Injury-Repair and Regeneration
[J].
Ahuja, Christopher S.
;
Nori, Satoshi
;
Tetreault, Lindsay
;
Wilson, Jefferson
;
Kwon, Brian
;
Harrop, James
;
Choi, David
;
Fehlings, Michael G.
.
NEUROSURGERY,
2017, 80 (03)
:S9-S22

Ahuja, Christopher S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, Canada
Univ Toronto, Dept Surg, Toronto, ON, Canada
Univ Toronto, Dept Genet & Dev, Toronto, ON, Canada Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

Nori, Satoshi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Genet & Dev, Toronto, ON, Canada Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

论文数: 引用数:
h-index:
机构:

Wilson, Jefferson
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada
Univ Toronto, Dept Surg, Toronto, ON, Canada
Univ Toronto, Spine Program, Toronto, ON, Canada Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

Kwon, Brian
论文数: 0 引用数: 0
h-index: 0
机构:
Vancouver Gen Hosp, Vancouver Spine Inst, Vancouver, BC, Canada
Univ British Columbia, Dept Surg, Vancouver, BC, Canada Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

论文数: 引用数:
h-index:
机构:

Choi, David
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Natl Hosp Neurol & Neurosurg, London, England Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

Fehlings, Michael G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, Canada
Univ Toronto, Dept Surg, Toronto, ON, Canada
Univ Toronto, Spine Program, Toronto, ON, Canada
Univ Toronto, Dept Genet & Dev, Toronto, ON, Canada Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada
[4]
The Role of Therapeutic Hypothermia After Traumatic Spinal Cord Injury-A Systematic Review
[J].
Alkabie, Samir
;
Boileau, Andrew J.
.
WORLD NEUROSURGERY,
2016, 86
:432-449

Alkabie, Samir
论文数: 0 引用数: 0
h-index: 0
机构:
Saba Univ, Sch Med, The Bottom, Saba, Netherlands Saba Univ, Sch Med, The Bottom, Saba, Netherlands

Boileau, Andrew J.
论文数: 0 引用数: 0
h-index: 0
机构:
Saba Univ, Sch Med, The Bottom, Saba, Netherlands Saba Univ, Sch Med, The Bottom, Saba, Netherlands
[5]
THE BIOLOGY OF REGENERATION FAILURE AND SUCCESS AFTER SPINAL CORD INJURY
[J].
Amanda Phuong Tran
;
Warren, Philippa Mary
;
Silver, Jerry
.
PHYSIOLOGICAL REVIEWS,
2018, 98 (02)
:881-917

Amanda Phuong Tran
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

Warren, Philippa Mary
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

Silver, Jerry
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA
[6]
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
[J].
Andreone, Benjamin J.
;
Chow, Brian Wai
;
Tata, Aleksandra
;
Lacoste, Baptiste
;
Ben-Zvi, Ayal
;
Bullock, Kevin
;
Deik, Amy A.
;
Ginty, David D.
;
Clish, Clary B.
;
Gu, Chenghua
.
NEURON,
2017, 94 (03)
:581-+

Andreone, Benjamin J.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Chow, Brian Wai
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Tata, Aleksandra
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Lacoste, Baptiste
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA
Univ Ottawa, Brain & Mind Res Inst, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Ben-Zvi, Ayal
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA
Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Dev Biol & Canc Res, IL-91120 Jerusalem, Israel Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Bullock, Kevin
论文数: 0 引用数: 0
h-index: 0
机构:
Broad Inst & Harvard, Cambridge, MA 02142 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Deik, Amy A.
论文数: 0 引用数: 0
h-index: 0
机构:
Broad Inst & Harvard, Cambridge, MA 02142 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Ginty, David D.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA
Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Clish, Clary B.
论文数: 0 引用数: 0
h-index: 0
机构:
Broad Inst & Harvard, Cambridge, MA 02142 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA

Gu, Chenghua
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA Harvard Med Sch, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA
[7]
The Blood-Spinal Cord Barrier: Morphology and Clinical Implications
[J].
Bartanusz, Viktor
;
Jezova, Daniela
;
Alajajian, Betty
;
Digicaylioglu, Murat
.
ANNALS OF NEUROLOGY,
2011, 70 (02)
:194-206

Bartanusz, Viktor
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA

Jezova, Daniela
论文数: 0 引用数: 0
h-index: 0
机构:
Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA

Alajajian, Betty
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA

Digicaylioglu, Murat
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA Univ Texas Hlth Sci Ctr San Antonio, Dept Neurosurg, San Antonio, TX 78229 USA
[8]
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
[J].
Bell, Robert D.
;
Winkler, Ethan A.
;
Sagare, Abhay P.
;
Singh, Itender
;
LaRue, Barb
;
Deane, Rashid
;
Zlokovic, Berislav V.
.
NEURON,
2010, 68 (03)
:409-427

Bell, Robert D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

Winkler, Ethan A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

Sagare, Abhay P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

Singh, Itender
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

LaRue, Barb
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

Deane, Rashid
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

Zlokovic, Berislav V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Neurol, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA Univ Rochester, Med Ctr, Dept Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA
[9]
UNDERSTANDING SECONDARY INJURY
[J].
Ben Borgens, Richard
;
Liu-Snyder, Peishan
.
QUARTERLY REVIEW OF BIOLOGY,
2012, 87 (02)
:89-127

Ben Borgens, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Sch Vet Med, Ctr Paralysis Res, W Lafayette, IN 47907 USA
Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA Purdue Univ, Sch Vet Med, Ctr Paralysis Res, W Lafayette, IN 47907 USA

Liu-Snyder, Peishan
论文数: 0 引用数: 0
h-index: 0
机构:
Brown Univ, Div Engn, Providence, RI 02912 USA Purdue Univ, Sch Vet Med, Ctr Paralysis Res, W Lafayette, IN 47907 USA
[10]
The history of therapeutic hypothermia and its use in neurosurgery
[J].
Bohl, Michael A.
;
Martirosyan, Nikolay L.
;
Killeen, Zachary W.
;
Belykh, Evgenii
;
Zabramski, Joseph M.
;
Spetzler, Robert F.
;
Preul, Mark C.
.
JOURNAL OF NEUROSURGERY,
2019, 130 (03)
:1006-1020

Bohl, Michael A.
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Martirosyan, Nikolay L.
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Killeen, Zachary W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Coll Med, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Belykh, Evgenii
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA
Irkutsk State Med Univ, Irkutsk, Russia St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Zabramski, Joseph M.
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Spetzler, Robert F.
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA

Preul, Mark C.
论文数: 0 引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA