Regulatory Function of Trefoil peptides (TFF) on Intestinal Cell Junctional Complexes

被引：37

作者：

Buda, Andrea ^{[2
]}

Jepson, Mark A. ^{[3
]}

Pignatelli, Massimo ^{[1
]}

机构：

[1] Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Bristol, Sch Clin Sci, Bristol, Avon, England

[3] Univ Bristol, Sch Biochem, Bristol, Avon, England

来源：

CELL COMMUNICATION AND ADHESION | 2012年 / 19卷 / 5-6期

关键词：

Trefoil peptides; adhesion molecules; tight junctions; E-CADHERIN; MUCOSAL ULCERATION; EPITHELIAL-CELLS; TIGHT JUNCTION; EXPRESSION; INDUCTION; ADHESION; CATENIN; MODULATION; INCREASES;

D O I：

10.3109/15419061.2012.748326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trefoil peptides (TFF) are constitutively expressed in the gastrointestinal tract and are involved in gastrointestinal defence and repair by promoting epithelial restitution. Although there is a general consensus regarding the pro-motogenic activity of trefoil peptides, the cellular mechanisms through which they mediate these processes are not completely understood. Pertubation of the E-cadherin/catenin complex at intercellular junctions appears to be a functional pathway through which TFF2 and TFF3 promote cell migration. Tight junction complexes seal the paracellular spaces between cells and contribute to epithelial barrier function. TFF3 peptide stimulation stabilises these junctions through upregulation of the tightening protein claudin-1 and redistribution of ZO-1 from the cytoplasm to the intercellular membrane with an increase in binding to occludin. Modulation of the functional activity and subcellular localisation of epithelial junctional adhesion molecules represent important mechanisms by which trefoil peptides may promote migration of intestinal epithelial cells in vitro and healing of mucosal damage in vivo

引用

页码：63 / 68

页数：6

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