Copper-Catalyzed Synthesis of 2-Arylquinazolinones from 2-Arylindoles with Amines or Ammoniums

被引：61

作者：

Feng, Yadong

Li, Yudong

Cheng, Guolin

Wang, Lianhui

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Key Lab Xiamen Marine & Gene Drugs, Inst Mol Med, Xiamen 361021, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 14期

关键词：

ONE-POT SYNTHESIS; QUINAZOLINE DERIVATIVES; SELECTIVE INHIBITORS; FACILE SYNTHESIS; QUINAZOLIN-4(3H)-ONES; REPLACEMENT; EFFICIENT; STRATEGY;

D O I：

10.1021/acs.joc.5b00957

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed synthesis of quinazolinones from easily available 2-arylindoles and amines or ammoniums has been developed, which provided various quinazolinones in up to 99% yields for 43 examples. This strategy features tolerance of a wide range of functional groups, easily available starting materials, simple operation, mild reaction conditions, and environmental friendliness.

引用

收藏

页码：7099 / 7107

页数：9

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