Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion

被引：18

作者：

Mudit, Mudit ^{[1
]}

El Sayed, Khalid A. ^{[2
]}

机构：

[1] DYouville Coll Sch Pharm, Dept Pharmaceut Social & Adm Sci, Buffalo, NY 14201 USA

[2] Univ Louisiana Monroe, Sch Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71201 USA

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 11期

关键词：

XESTOSPONGIA-EXIGUA KIRKPATRICK; RICH CYCLIC OCTAPEPTIDE; MOTUPORAMINES A-C; BREAST-CANCER; DRUG DISCOVERY; IN-VITRO; PHENYLMETHYLENE HYDANTOINS; MESENCHYMAL TRANSITION; BIOLOGICAL-PROPERTIES; ANTICANCER AGENTS;

D O I：

10.1016/j.drudis.2016.06.032

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The marine environment is a reliable source for the discovery of novel treatment options for numerous diseases. Past research efforts toward the discovery of marine-derived anticancer agents have resulted in several commercially available marine-based drugs. The pharmaceutical value of anticancer drugs from marine natural products (MNPs) ranges from US$563 billion to US$5.69 trillion. In this review, we highlight several marine-derived entities with the potential for cancer control and prevention through the inhibition of crucial tumor cell motility and/or migration steps involved in subsequent cancer metastases. This report also covers the major hurdles typically faced by the MNPs research scientific community.

引用

页码：1745 / 1760

页数：16

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