The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

被引：16

作者：

Rausch, Magdalena ^{[1
]}

Samodelov, Sophia L. ^{[1
]}

Visentin, Michele ^{[1
]}

Kullak-Ublick, Gerd A. ^{[1
]}

机构：

[1] Univ Zurich, Univ Hosp Zurich, Dept Clin Pharmacol & Toxicol, CH-8006 Zurich, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 22期

基金：

瑞士国家科学基金会;

关键词：

drug-induced liver injury; farnesoid X receptor (FXR); hepatotoxicity; inflammation; liver; NAFLD and NASH; SALT EXPORT PUMP; MULTIDRUG-RESISTANCE PROTEIN-3; INDUCED HEPATIC STEATOSIS; BILE-ACID SYNTHESIS; NUCLEAR RECEPTOR; FATTY LIVER; OBETICHOLIC ACID; UP-REGULATION; NONALCOHOLIC STEATOHEPATITIS; TRANSCRIPTIONAL REGULATION;

D O I：

10.3390/ijms232213967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. Furthermore, FXR represents a real guardian of the hepatic function, preserving, in a multifactorial fashion, the integrity and function of hepatocytes from chronic and acute insults. This review summarizes how FXR modulates the expression of pathway-specific as well as polyspecific transporters and enzymes, thereby acting at the interface of BA, lipid and drug metabolism, and influencing the onset and progression of hepatotoxicity of varying etiopathogeneses. Furthermore, this review article provides an overview of the advances and the clinical development of FXR agonists in the treatment of liver diseases.

引用

页数：19

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