How should we assess the impact of genetic changes on ageing in model species?

被引：17

作者：

Minois, N ^{[1
]}

机构：

[1] Austrian Acad Sci, Inst Mol Biotechnol, Dickson Lab, A-1030 Vienna, Austria

来源：

AGEING RESEARCH REVIEWS | 2006年 / 5卷 / 01期

关键词：

ageing; longevity; age-specific measurements; multi-dimensional approach;

D O I：

10.1016/j.arr.2005.08.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the most active branches of genetic research is the quest for the genetic determinants of ageing. The ultimate goal of much of this effort is to understand ageing in humans. In addition to work on human genetics, many researchers look to model organisms in order to find genetic variation that can affect ageing. The fly Drosophila, the worm Caenorhabditis elegans, rodents, and yeast are among the most widely studied species. However, while great care is given to the genetic aspects of this form of research, the methods used to assess the impact of the genetic changes on the organism in question do not always provide as complete a picture as possible of ageing's multi-facetted nature. In this commentary, I propose a systematic and rigorous approach, and draw attention to research that has already demonstrated the value of such an approach. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 59

页数：8

共 26 条

[1] Dissociation between functional senescence and oxidative stress resistance in Drosophila [J].

Cook-Wiens, E ;

Grotewiel, MS .

EXPERIMENTAL GERONTOLOGY, 2002, 37 (12) :1347-1357

[2] Rates of behavior and aging specified by mitochondrial function during development [J].

Dillin, A ;

Hsu, AL ;

Arantes-Oliveira, NA ;

Lehrer-Graiwer, J ;

Hsin, H ;

Fraser, AG ;

Kamath, RS ;

Ahringer, J ;

Kenyon, C .

SCIENCE, 2002, 298 (5602) :2398-2401

[3] Interpreting interactions between treatments that slow aging [J].

Gems, D ;

Pletcher, S ;

Partridge, L .

AGING CELL, 2002, 1 (01) :1-9

[4] In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans [J].

Gerstbrein, B ;

Stamatas, G ;

Kollias, N ;

Driscoll, M .

AGING CELL, 2005, 4 (03) :127-137

[5] Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty [J].

Glenn, CF ;

Chow, DK ;

David, L ;

Cooke, CA ;

Gami, MS ;

Iser, WB ;

Hanselman, KB ;

Goldberg, IG ;

Wolkow, CA .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2004, 59 (12) :1251-1260

[6] Delayed behavioural aging and altered mortality in Drosophila β integrin mutants [J].

Goddeeris, MM ;

Cook-Wiens, E ;

Horton, WJ ;

Wolf, H ;

Stoltzfus, JR ;

Borrusch, M ;

Grotewiel, MS .

AGING CELL, 2003, 2 (05) :257-264

[7] Stochastic and genetic factors influence tissue-specific decline in ageing C-elegans [J].

Herndon, LA ;

Schmeissner, PJ ;

Dudaronek, JM ;

Brown, PA ;

Listner, KM ;

Sakano, Y ;

Paupard, MC ;

Hall, DH ;

Driscoll, M .

NATURE, 2002, 419 (6909) :808-814

[8] Regulation of aging and age-related disease by DAF-16 and heat-shock factor [J].

Hsu, AL ;

Murphy, CT ;

Kenyon, C .

SCIENCE, 2003, 300 (5622) :1142-1145

[9] Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans [J].

Huang, C ;

Xiong, CJ ;

Kornfeld, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (21) :8084-8089

[10] Long lifespan in worms with long telomeric DNA [J].

Joeng, KS ;

Song, EJ ;

Lee, KJ ;

Lee, J .

NATURE GENETICS, 2004, 36 (06) :607-611

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