The neurovascular unit and combination treatment strategies for stroke

被引：136
作者：
Zhang, Li [1 ]
Zhang, Zheng Gang [1 ]
Chopp, Michael [1 ,2 ]
机构：
[1] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
[2] Oakland Univ, Dept Phys, Rochester, MI 48309 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2012年 / 33卷 / 08期
关键词：
TISSUE-PLASMINOGEN-ACTIVATOR; BLOOD-BRAIN-BARRIER; FOCAL CEREBRAL-ISCHEMIA; TOLL-LIKE RECEPTORS; AGE-RELATED-CHANGES; PROTEASOME INHIBITION; HEMORRHAGIC TRANSFORMATION; THROMBOLYTIC THERAPY; RAT MODEL; MATRIX-METALLOPROTEINASE;
D O I：
10.1016/j.tips.2012.04.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tissue plasminogen activator (tPA) administered within 4.5 h of symptom onset restores cerebral blood flow (CBF) and promotes neurological recovery of stroke patients. However, the narrow therapeutic time window and the risk of intracerebral hemorrhage after tPA treatment pose major hurdles to its clinical usage. In light of the failures of neuroprotective therapies in clinical trials, emerging concepts suggest that neuroprotection alone without restoration of tissue perfusion and vascular integrity may not be adequate for treatment of acute stroke. Here we review evidence of the use of adjuvant pharmacological agents to extend the therapeutic window for tPA via targeting the neurovascular unit and the underlying mechanisms of the combination therapy in experimental stroke.
引用
收藏
页码：415 / 422
页数：8
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