共 130 条
Pathology and Molecular Genetics of Pancreatic Neoplasms
被引:127
作者:

Wood, Laura D.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

Hruban, Ralph H.
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h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA
机构:
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA
关键词:
Pancreatic neoplasms;
pancreatic cancer genomes;
PAPILLARY-MUCINOUS NEOPLASMS;
TUMOR-SUPPRESSOR GENE;
COMPARATIVE GENOMIC HYBRIDIZATION;
SOLID PSEUDOPAPILLARY TUMOR;
ACINAR-CELL-CARCINOMA;
K-RAS MUTATIONS;
E-CADHERIN EXPRESSION;
BETA-CATENIN GENE;
INTRAEPITHELIAL NEOPLASIA;
CYSTIC NEOPLASMS;
D O I:
10.1097/PPO.0b013e31827459b6
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Cancer is fundamentally a genetic disease caused by the accumulation of somatic mutations in oncogenes and tumor suppressor genes. In the last decade, rapid advances in sequencing and bioinformatic technology led to an explosion in sequencing studies of cancer genomes, greatly expanding our knowledge of the genetic changes underlying a variety of tumor types. Several of these studies of cancer genomes have focused on pancreatic neoplasms, and cancers from the pancreas are some of the best characterized tumors at the genetic level. Pancreatic neoplasms encompass a wide array of clinical diseases, from benign cysts to deadly cancers, and the genetic alterations underlying neoplasms of the pancreas are similarly diverse. This new knowledge of pancreatic cancer genomes has deepened our understanding of tumorigenesis in the pancreas and has opened several promising new avenues for novel diagnostics and therapeutics.
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页码:492 / 501
页数:10
相关论文
共 130 条
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