2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents

被引：94

作者：

Goel, B

Ram, T

Tyagi, R

Bansal, E

Kumar, A ^{[1
]}

Mukherjee, D

Sinha, JN

机构：

[1] LLRM, Coll Med, Dept Pharmacol, Meerut 250004, Uttar Pradesh, India

[2] KG Med Coll, Dept Pharmacol & Therapeut, Lucknow 226003, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 03期

关键词：

thiazolidinones; anti-inflammatory; ulcerogenic; cardiovascular; behavioural activities; acute toxicity;

D O I：

10.1016/S0223-5234(99)80060-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-inflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-fluorophenyl)-5-methyl-4-thiazolidinone 6 was compared with phenylbutazone for its relative antiinflammatory potency and ulcerogenic liability. ED50, cardiovascular and central nervous system effects of 6 were also studied. (C) Elsevier, Paris.

引用

页码：265 / 269

页数：5