共 95 条
Thinking outside the cell: how cadherins drive adhesion
被引:252
作者:

Brasch, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

Harrison, Oliver J.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

Honig, Barry
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

Shapiro, Lawrence
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
机构:
[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
[2] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
[3] Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA
基金:
美国国家科学基金会;
美国国家卫生研究院;
关键词:
II CLASSIC CADHERINS;
ADHERENS JUNCTIONS;
STRUCTURAL BASIS;
FUNCTIONAL-ANALYSIS;
ALPHA-CATENIN;
T-CADHERIN;
BINDING;
DOMAIN;
SPECIFICITY;
MECHANISM;
D O I:
10.1016/j.tcb.2012.03.004
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of beta-sandwich extracellular cadherin (EC) domains that adopt a similar fold to immunoglobulin domains. The best characterized cadherins are the vertebrate 'classical' cadherins, which mediate adhesion via trans homodimerization between their membrane-distal EC1 domains that extend from apposed cells, and assemble intercellular adherens junctions through cis clustering. To form mature trans adhesive dimers, cadherin domains from apposed cells dimerize in a 'strand-swapped' conformation. This occurs in a two-step binding process involving a fast-binding intermediate called the 'X-dimer'. Trans dimers are less flexible than cadherin monomers, a factor that drives junction assembly following cell cell contact by reducing the entropic cost associated with the formation of lateral cis oligomers. Cadherins outside the classical subfamily appear to have evolved distinct adhesive mechanisms that are only now beginning to be understood.
引用
收藏
页码:299 / 310
页数:12
相关论文
共 95 条
[11]
T-cadherin structures reveal a novel adhesive binding mechanism
[J].
Ciatto, Carlo
;
Bahna, Fabiana
;
Zampieri, Niccolo
;
VanSteenhouse, Harper C.
;
Katsamba, Phini S.
;
Ahlsen, Goran
;
Harrison, Oliver J.
;
Brasch, Julia
;
Jin, Xiangshu
;
Posy, Shoshana
;
Vendome, Jeremie
;
Ranscht, Barbara
;
Jessell, Thomas M.
;
Honig, Barry
;
Shapiro, Lawrence
.
NATURE STRUCTURAL & MOLECULAR BIOLOGY,
2010, 17 (03)
:339-U110

Ciatto, Carlo
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Bahna, Fabiana
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Zampieri, Niccolo
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Dept Neurosci, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

VanSteenhouse, Harper C.
论文数: 0 引用数: 0
h-index: 0
机构:
Burnham Inst Med Res, La Jolla, CA USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Katsamba, Phini S.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Ahlsen, Goran
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Harrison, Oliver J.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Brasch, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Jin, Xiangshu
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Posy, Shoshana
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Vendome, Jeremie
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Ranscht, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Burnham Inst Med Res, La Jolla, CA USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Jessell, Thomas M.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
Columbia Univ, Dept Neurosci, New York, NY 10032 USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Honig, Barry
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA

Shapiro, Lawrence
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Columbia Univ, Edward S Harkness Eye Inst, New York, NY USA Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA
[12]
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members
[J].
Elledge, Heather M.
;
Kazmierczak, Piotr
;
Clark, Peter
;
Joseph, Jeremiah S.
;
Kolatkar, Anand
;
Kuhn, Peter
;
Mueller, Ulrich
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2010, 107 (23)
:10708-10712

Elledge, Heather M.
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Dorris Neurosci Ctr, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Kazmierczak, Piotr
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Dorris Neurosci Ctr, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Clark, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Joseph, Jeremiah S.
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Kolatkar, Anand
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Kuhn, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Mueller, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Dorris Neurosci Ctr, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
[13]
A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion
[J].
Emond, Michelle R.
;
Biswas, Sayantanee
;
Blevins, Cheasequah J.
;
Jontes, James D.
.
JOURNAL OF CELL BIOLOGY,
2011, 195 (07)
:1115-1121

Emond, Michelle R.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA

论文数: 引用数:
h-index:
机构:

Blevins, Cheasequah J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA

Jontes, James D.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA
Ohio State Univ, Mol Cellular & Dev Biol Grad Program, Columbus, OH 43210 USA Ohio State Univ, Sch Biomed Sci, Dept Neurosci, Columbus, OH 43210 USA
[14]
Monoallelic yet combinatorial expression of variable exons of the protocadherin-α gene cluster in single neurons
[J].
Esumi, S
;
Kakazu, N
;
Taguchi, Y
;
Hirayama, T
;
Sasaki, A
;
Hirabayashi, T
;
Koide, T
;
Kitsukawa, T
;
Hamada, S
;
Yagi, T
.
NATURE GENETICS,
2005, 37 (02)
:171-176

Esumi, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Kakazu, N
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Taguchi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Hirayama, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Sasaki, A
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Hirabayashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Koide, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Kitsukawa, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Hamada, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

Yagi, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan
[15]
Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure
[J].
Garrod, DR
;
Berika, MY
;
Bardsley, WF
;
Holmes, D
;
Tabernero, L
.
JOURNAL OF CELL SCIENCE,
2005, 118 (24)
:5743-5754

Garrod, DR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

Berika, MY
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

Bardsley, WF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

Holmes, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

Tabernero, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
[16]
Regulation of cadherin-mediated adhesion in morphogenesis
[J].
Gumbiner, BM
.
NATURE REVIEWS MOLECULAR CELL BIOLOGY,
2005, 6 (08)
:622-634

Gumbiner, BM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA
[17]
Cadherin and catenin alterations in human cancer
[J].
Hajra, KM
;
Fearon, ER
.
GENES CHROMOSOMES & CANCER,
2002, 34 (03)
:255-268

Hajra, KM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Sch, Program Cellular & Mol Biol, Ann Arbor, MI USA

Fearon, ER
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Med Sch, Program Cellular & Mol Biol, Ann Arbor, MI USA
[18]
VE-cadherin: at the front, center, and sides of endothelial cell organization and function
[J].
Harris, Elizabeth S.
;
Nelson, W. James
.
CURRENT OPINION IN CELL BIOLOGY,
2010, 22 (05)
:651-658

Harris, Elizabeth S.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol, James H Clark Ctr, Bio X Program, Stanford, CA 94305 USA Stanford Univ, Dept Biol, James H Clark Ctr, Bio X Program, Stanford, CA 94305 USA

Nelson, W. James
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol, James H Clark Ctr, Bio X Program, Stanford, CA 94305 USA Stanford Univ, Dept Biol, James H Clark Ctr, Bio X Program, Stanford, CA 94305 USA
[19]
Adherens junctions: from molecules to morphogenesis
[J].
Harris, Tony J. C.
;
Tepass, Ulrich
.
NATURE REVIEWS MOLECULAR CELL BIOLOGY,
2010, 11 (07)
:502-514

Harris, Tony J. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada

Tepass, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada
[20]
Cadherin adhesion depends on a salt bridge at the N-terminus
[J].
Harrison, OJ
;
Corps, EM
;
Kilshaw, PJ
.
JOURNAL OF CELL SCIENCE,
2005, 118 (18)
:4123-4130

Harrison, OJ
论文数: 0 引用数: 0
h-index: 0
机构:
Babraham Inst, Cambridge CB2 4AT, England Babraham Inst, Cambridge CB2 4AT, England

Corps, EM
论文数: 0 引用数: 0
h-index: 0
机构:
Babraham Inst, Cambridge CB2 4AT, England Babraham Inst, Cambridge CB2 4AT, England

Kilshaw, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
Babraham Inst, Cambridge CB2 4AT, England Babraham Inst, Cambridge CB2 4AT, England