ACTH versus vigabatrin therapy in infantile spasms: A retrospective study

被引：52

作者：

Cossette, P

Riviello, JJ

Carmant, L

机构：

[1] Univ Montreal, Hop St Justine, Dept Pediat Neurol, Montreal, PQ H3T 1C5, Canada

[2] Harvard Univ, Childrens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

NEUROLOGY | 1999年 / 52卷 / 08期

关键词：

D O I：

10.1212/WNL.52.8.1691

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

ACTH is the standard treatment for infantile spasms (IS) in North America. Recent reports showed that vigabatrin is a valuable treatment for IS, but comparative studies with ACTH are limited. In this study, we compare the effectiveness of ACTH versus vigabatrin on IS. Our results support that vigabatrin is as effective as and better tolerated than ACTH. Because of their similar efficacy, we believe that vigabatrin should be the first intention drug for the treatment of IS.

引用

页码：1691 / 1694

页数：4

共 10 条

[1] Vigabatrin as initial therapy for infantile spasms: A European retrospective survey [J].

Aicardi, J ;

Hauser, E ;

Steinbock, H ;

Szyper, M ;

Holsteen, V ;

Ostergaard, J ;

Pedersen, SA ;

Taudorf, K ;

BarthezCarpentier, MA ;

BadinandHubert, N ;

Berquin, P ;

Boulloche, J ;

Bourgeois, M ;

Carriere, JP ;

Chabrol, B ;

Chiron, C ;

Claris, O ;

Echenne, B ;

GauthierMorel, D ;

Livet, MO ;

Lopez, N ;

Mancini, J ;

Netter, JC ;

Quillerou, D ;

Richelme, CH ;

Rousselle, C ;

DeStMartin, A ;

DeSwarte, M ;

Auerswald, G ;

Brandl, U ;

Kurlemann, G ;

Siemes, H ;

Spohr, HL ;

Aarts, WFM ;

Begeer, JH ;

Heersma, DJ ;

Laan, LAEM ;

Peters, ACB ;

Cavazzutti, GB ;

Curatolo, P ;

Fois, A ;

Franzoni, E ;

Gobbi, G ;

Incorpora, G ;

Vigevano, F ;

Campistol, J ;

Campos, J ;

Casas, C ;

Herranz, JL ;

Nieto, M .

EPILEPSIA, 1996, 37 (07) :638-642

[2] HIGH-DOSE B6 TREATMENT IN INFANTILE SPASMS [J].

BLENNOW, G ;

STARCK, L .

NEUROPEDIATRICS, 1986, 17 (01) :7-10

[3] Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis [J].

Chiron, C ;

Dumas, C ;

Jambaque, I ;

Mumford, J ;

Dulac, O .

EPILEPSY RESEARCH, 1997, 26 (02) :389-395

[4] INFANTILE SPASMS - COMPARATIVE TRIAL OF NITRAZEPAM AND CORTICOTROPIN [J].

DREIFUSS, F ;

FARWELL, J ;

HOLMES, G ;

JOSEPH, C ;

LOCKMAN, L ;

MADSEN, JA ;

MINARCIK, CJ ;

ROTHNER, AD ;

SHEWMON, DA .

ARCHIVES OF NEUROLOGY, 1986, 43 (11) :1107-1110

[5] THE NEUROSTEROID 3-ALPHA,5-ALPHA-THP HAS ANTISEIZURE AND POSSIBLE NEUROPROTECTIVE EFFECTS IN AN ANIMAL-MODEL OF EPILEPSY [J].

FRYE, CA .

BRAIN RESEARCH, 1995, 696 (1-2) :113-120

[6] A CONTROLLED-STUDY OF ACTH THERAPY IN INFANTILE SPASMS [J].

HRACHOVY, RA ;

FROST, JD ;

KELLAWAY, P ;

ZION, T .

EPILEPSIA, 1980, 21 (06) :631-636

[7] LONG-TERM PROGNOSIS OF 150 CASES OF WEST SYNDROME [J].

JEAVONS, PM ;

BOWER, BD ;

DIMITRAKOUDI, M .

EPILEPSIA, 1973, 14 (02) :153-164

[8] A PROSPECTIVE-STUDY OF INFANTILE SPASMS - CLINICAL AND THERAPEUTIC CORRELATIONS [J].

LOMBROSO, CT .

EPILEPSIA, 1983, 24 (02) :135-158

[9] THERAPY OF INFANTILE SPASMS WITH VALPROATE - RESULTS OF A PROSPECTIVE-STUDY [J].

SIEMES, H ;

SPOHR, HL ;

MICHAEL, T ;

NAU, H .

EPILEPSIA, 1988, 29 (05) :553-560

[10]

Vigevano F, 1997, EPILEPSIA, V38, P1270

← 1 →