Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

被引：75
作者：
de Assis Lima, Isabel Vieira [1 ]
Silva Bastos, Leandro Francisco [2 ,3 ]
Limborco-Filho, Marcelo [2 ]
Fiebich, Bernd L. [4 ,5 ]
Pinheiro de Oliveira, Antonio Carlos [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA
[4] Univ Freiburg, Sch Med, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany
[5] VivaCell Biotechnol GmbH, D-79211 Denzlingen, Germany
来源：
MEDIATORS OF INFLAMMATION | 2012年 / 2012卷
关键词：
ACTIVATED-RECEPTOR-GAMMA; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CYTOSOLIC PHOSPHOLIPASE A(2); EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA PEPTIDES; AMYOTROPHIC-LATERAL-SCLEROSIS; OXIDE SYNTHASE EXPRESSION;
D O I：
10.1155/2012/946813
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.
引用
收藏
页数：13
相关论文
共 172 条
[81]  
Lee RKK, 1999, J NEUROSCI, V19, P940
[82]   Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2α exacerbate hypoxic neuronal injury in neuron-enriched primary culture [J].
Li, Wenjin ;
Wu, Shasha ;
Hickey, Robert W. ;
Rose, Marie E. ;
Chen, Jun ;
Graham, Steven H. .
NEUROCHEMICAL RESEARCH, 2008, 33 (03) :490-499
[83]   Δ12-prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition [J].
Li, ZM ;
Melandri, F ;
Berdo, I ;
Jansen, M ;
Hunter, L ;
Wright, S ;
Valbrun, D ;
Figueiredo-Pereira, ME .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 319 (04) :1171-1180
[84]   The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis [J].
Liang, Xibin ;
Wang, Qian ;
Shi, Ju ;
Lokteva, Ludmila ;
Breyer, Richard M. ;
Montine, Thomas J. ;
Andreasson, Katrin .
ANNALS OF NEUROLOGY, 2008, 64 (03) :304-314
[85]   The role of inflammation in CNS injury and disease [J].
Lucas, SM ;
Rothwell, NJ ;
Gibson, RM .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 :S232-S240
[86]   3-NITROPROPIONIC ACID - EXOGENOUS ANIMAL NEUROTOXIN AND POSSIBLE HUMAN STRIATAL TOXIN [J].
LUDOLPH, AC ;
HE, F ;
SPENCER, PS ;
HAMMERSTAD, J ;
SABRI, M .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1991, 18 (04) :492-498
[87]   Microglia in the aging brain: relevance to neurodegeneration [J].
Luo, Xiao-Guang ;
Ding, Jian-Qing ;
Chen, Sheng-Di .
MOLECULAR NEURODEGENERATION, 2010, 5
[88]   Microglia density decreases with age in a mouse model of Huntington's disease [J].
Ma, L ;
Morton, AJ ;
Nicholson, LFB .
GLIA, 2003, 43 (03) :274-280
[89]   Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence [J].
Machado, A. ;
Herrera, A. J. ;
Venero, J. L. ;
Santiago, M. ;
De Pablos, R. M. ;
Villaran, R. F. ;
Espinosa-Oliva, A. M. ;
Argueelles, S. ;
Sarmiento, M. ;
Delgado-Cortes, M. J. ;
Maurino, R. ;
Cano, J. .
PARKINSONS DISEASE, 2011, 2011
[90]   Expression and localization of cyclooxygenase-1 and-2 in human sporadic amyotrophic lateral sclerosis [J].
Maihöfner, C ;
Probst-Cousin, S ;
Bergmann, M ;
Neuhuber, W ;
Neundörfer, B ;
Heuss, D .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (06) :1527-1534
45678910111213