Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

被引：72

作者：

de Assis Lima, Isabel Vieira ^{[1
]}

Silva Bastos, Leandro Francisco ^{[2
,3
]}

Limborco-Filho, Marcelo ^{[2
]}

Fiebich, Bernd L. ^{[4
,5
]}

Pinheiro de Oliveira, Antonio Carlos ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[4] Univ Freiburg, Sch Med, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany

[5] VivaCell Biotechnol GmbH, D-79211 Denzlingen, Germany

来源：

MEDIATORS OF INFLAMMATION | 2012年 / 2012卷

关键词：

ACTIVATED-RECEPTOR-GAMMA; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CYTOSOLIC PHOSPHOLIPASE A(2); EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA PEPTIDES; AMYOTROPHIC-LATERAL-SCLEROSIS; OXIDE SYNTHASE EXPRESSION;

D O I：

10.1155/2012/946813

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.

引用

页数：13

共 172 条

[1] Identification of actin as a 15-deoxy-Δ12,14-prostaglandin J2 target in neuroblastoma cells:: Mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement [J].

Aldini, Giancarlo ;

Carini, Marina ;

Vistoli, Giulio ;

Shibata, Takahiro ;

Kusano, Yuri ;

Gamberoni, Luca ;

Dalle-Donne, Isabella ;

Milzani, Aldo ;

Uchida, Koji .

BIOCHEMISTRY, 2007, 46 (10) :2707-2718

[2] Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients [J].

Almer, G ;

Teismann, P ;

Stevic, Z ;

Halaschek-Wiener, J ;

Deecke, L ;

Kostic, V ;

Przedborski, S .

NEUROLOGY, 2002, 58 (08) :1277-1279

[3]

Almer G, 2001, ANN NEUROL, V49, P176, DOI 10.1002/1531-8249(20010201)49:2<176::AID-ANA37>3.0.CO

[4]

2-X

[5] Is prostaglandin E2 a pathogenic factor in amyotrophic lateral sclerosis? [J].

Almer, Gabriele ;

Kikuchi, Hitoshi ;

Teismann, Peter ;

Przedborski, Serge .

ANNALS OF NEUROLOGY, 2006, 59 (06) :980-983

[6] Oxidative stress in neurodegeneration: cause or consequence? [J].

Andersen, JK .

NATURE MEDICINE, 2004, 10 (07) :S18-S25

[7] Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE) [J].

Ayoub, Samir S. ;

Wood, Elizabeth G. ;

Hassan, Sabih-Ul ;

Bolton, Christopher .

INFLAMMATION RESEARCH, 2011, 60 (10) :919-928

[8] Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS [J].

Azari, MF ;

Profyris, C ;

Le Grande, MR ;

Lopes, EC ;

Hirst, J ;

Petratos, S ;

Cheema, SS .

EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 (05) :357-364

[9] Minocycline in phenotypic models of Huntington's disease [J].

Bantubungi, K ;

Jacquard, C ;

Greco, A ;

Pintor, A ;

Chtarto, A ;

Tai, K ;

Galas, MC ;

Tenenbaum, L ;

Déglon, N ;

Popoli, P ;

Minghetti, L ;

Brouillet, E ;

Brotchi, J ;

Levivier, M ;

Scbiffmann, SN ;

Blum, D .

NEUROBIOLOGY OF DISEASE, 2005, 18 (01) :206-217

[10] Role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and its natural ligand 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of microglial functions [J].

Bernardo, A ;

Levi, G ;

Minghetti, L .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (07) :2215-2223

← 1 2 3 4 5 6 7 8 9 10 →