Surrogate markers of disease in mastocytosis

被引：43
作者：
Akin, C [1 ]
Metcalfe, DD [1 ]
机构：
[1] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2002年 / 127卷 / 02期
关键词：
mastocytosis; urticaria pigmentosa; surrogate markers; tryptase; mast cells;
D O I：
10.1159/000048184
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Measurement of surrogate mast cell-related products in blood or urine is often performed to assess disease extent in evaluating patients with mastocytosis. Serum tryptase and 24-hour urine histamine metabolites are the most commonly used surrogate markers of mastocytosis. In addition, several novel markers including soluble CD117 and soluble CD25 have been identified in recent studies. The utility and the pitfalls of each of these measurements are discussed. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：133 / 136
页数：4
相关论文
共 22 条
[1]   Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis [J].
Akin, C ;
Kirshenbaum, AS ;
Semere, T ;
Worobec, AS ;
Scott, LM ;
Metcalfe, DD .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (02) :140-147
[2]   Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology [J].
Akin, C ;
Schwartz, LB ;
Kitoh, T ;
Obayashi, H ;
Worobec, AS ;
Scott, LM ;
Metcalfe, DD .
BLOOD, 2000, 96 (04) :1267-1273
[3]   Indolent systemic mast cell disease in adults:: Immunophenotypic characterization of bone marrow mast cells and its diagnostic implications [J].
Escribano, L ;
Orfao, A ;
Díaz-Agustin, B ;
Villarrubia, J ;
Cerveró, C ;
López, A ;
Marcos, MAG ;
Bellas, C ;
Fernández-Cañadas, S ;
Cuevas, M ;
Sánchez, A ;
Velasco, JL ;
Navarro, JL ;
San Miguel, JF .
BLOOD, 1998, 91 (08) :2731-2736
[4]   STUDIES ON HISTAMINE-METABOLISM IN MASTOCYTOSIS [J].
GRANERUS, G ;
OLAFSSON, JH ;
ROUPE, G .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 80 (05) :410-416
[5]  
Granerus G, 1998, BRIT J DERMATOL, V139, P858
[6]   IMPROVED DIAGNOSIS OF MASTOCYTOSIS BY MEASUREMENT OF URINARY HISTAMINE METABOLITES [J].
KEYZER, JJ ;
DEMONCHY, JGR ;
VANDOORMAAL, JJ ;
VANVOORSTVADER, PC .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (26) :1603-1605
[7]   Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm [J].
Longley, BJ ;
Tyrrell, L ;
Lu, SZ ;
Ma, YS ;
Langley, K ;
Ding, TG ;
Duffy, T ;
Jacobs, P ;
Tang, LH ;
Modlin, I .
NATURE GENETICS, 1996, 12 (03) :312-314
[8]   Mastocytosis: molecular mechanisms and clinical disease heterogeneity [J].
Metcalfe, DD ;
Akin, C .
LEUKEMIA RESEARCH, 2001, 25 (07) :577-582
[9]   IMPROVED DIAGNOSIS OF MASTOCYTOSIS BY MEASUREMENT OF THE MAJOR URINARY METABOLITE OF PROSTAGLANDIN D-2 [J].
MORROW, JD ;
GUZZO, C ;
LAZARUS, G ;
OATES, JA ;
ROBERTS, LJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (06) :937-940
[10]   Increased formation of thromboxane in vivo in humans with mastocytosis [J].
Morrow, JD ;
Oates, JA ;
Roberts, LJ ;
Zackert, WE ;
Mitchell, TA ;
Lazarus, G ;
Guzzo, C .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (01) :93-97
123