Metastatic pathways in patients with cutaneous melanoma

被引：41

作者：

Adler, Nikki R. ^{[1
,2
]}

Haydon, Andrew ^{[1
,3
]}

McLean, Catriona A. ^{[4
]}

Kelly, John W. ^{[1
]}

Mar, Victoria J. ^{[1
,2
,5
]}

机构：

[1] Alfred Hosp, Victorian Melanoma Serv, Melbourne, Vic, Australia

[2] Monash Univ, Sch Publ Hlth & Prevent Med, Alfred Hosp, Melbourne, Vic, Australia

[3] Alfred Hosp, Dept Med Oncol, Melbourne, Vic, Australia

[4] Alfred Hosp, Dept Anat Pathol, Melbourne, Vic, Australia

[5] Skin & Canc Fdn, Carlton, Vic, Australia

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2017年 / 30卷 / 01期

关键词：

cutaneous melanoma/; metastasis/; metastatic pathways/; biomarker; CIRCULATING TUMOR-CELLS; SENTINEL-NODE BIOPSY; EXTRAVASCULAR MIGRATORY METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN; NRAS MUTATIONS; MALIGNANT-MELANOMA; BRAF MUTATIONS; PROGNOSTIC-SIGNIFICANCE; ULTRAVIOLET-RADIATION;

D O I：

10.1111/pcmr.12544

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis represents the end product of an elaborate biological process, which is determined by a complex interplay between metastatic tumour cells, host factors and homoeostatic mechanisms. Cutaneous melanoma can metastasize haematogenously or lymphogenously. The three predominant models that endeavour to explain the patterns of melanoma progression are the stepwise spread model, the simultaneous spread model and the model of differential spread. The time course to the development of metastases differs between the different metastatic routes. There are several clinical and histopathological risk factors for the different metastatic pathways. In particular, patient sex and the anatomical location of the primary tumour influence patterns of disease progression. There is limited existing evidence regarding the relationship between tumour mutation status, other diagnostic and prognostic biomarkers and the metastatic pathways of primary cutaneous melanoma. This knowledge gap needs to be addressed to better identify patients at high risk of disease recurrence and personalize surveillance strategies.

引用

页码：13 / 27

页数：15

共 156 条

[1] Prognostic implications of epithelial to mesenchymal transition related proteins (E-cadherin, Snail) and hypoxia inducible factor 1α in endometrioid endometrial carcinoma [J].

Abouhashem, Nehal S. ;

Ibrahim, Doaa Abdelaziz ;

Mohamed, Abdel Motaleb .

ANNALS OF DIAGNOSTIC PATHOLOGY, 2016, 22 :1-11

[2] p16 Expression: A marker of differentiation between childhood malignant melanomas and Spitz nevi [J].

Al Dhaybi, Rola ;

Agoumi, Mehdi ;

Gagne, Isabelle ;

McCuaig, Catherine ;

Powell, Julie ;

Kokta, Victor .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 65 (02) :357-363

[3] OPINION Challenges in circulating tumour cell research [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

NATURE REVIEWS CANCER, 2014, 14 (09) :623-631

[4] Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review) [J].

Allegra, Alessandro ;

Alonci, Andrea ;

Campo, Salvatore ;

Penna, Giuseppa ;

Petrungaro, Annamaria ;

Gerace, Demetrio ;

Musolino, Caterina .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (06) :1897-1912

[5] A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis [J].

Alonso, Soledad R. ;

Tracey, Lorraine ;

Ortiz, Pablo ;

Perez-Gomez, Beatriz ;

Palacios, Jose ;

Pollan, Marina ;

Linares, Juan ;

Serrano, Salvio ;

Saez-Castillo, Ana I. ;

Sanchez, Lydia ;

Pajares, Raquel ;

Sanchez-Aguilera, Abel ;

Artiga, Maria J. ;

Piris, Miguel A. ;

Rodriguez-Peralto, Jose L. .

CANCER RESEARCH, 2007, 67 (07) :3450-3460

[6] Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence [J].

Ansieau, Stephane ;

Bastid, Jeremy ;

Doreau, Agnes ;

Morel, Anne-Pierre ;

Bouchet, Benjamin P. ;

Thomas, Clemence ;

Fauvet, Frederique ;

Puisieux, Isabelle ;

Doglioni, Claudio ;

Piccinin, Sara ;

Maestro, Roberta ;

Voeltzel, Thibault ;

Selmi, Abdelkader ;

Valsesia-Wittmann, Sandrine ;

de Fromentel, Claude Caron ;

Puisieux, Alain .

CANCER CELL, 2008, 14 (01) :79-89

[7] Identification of a Circulating MicroRNA Profile as a Biomarker of Metastatic Cutaneous Melanoma [J].

Armand-Labit, Virginie ;

Meyer, Nicolas ;

Casanova, Anne ;

Bonnabau, Henri ;

Platzer, Valerie ;

Tournier, Emilie ;

Sansas, Benoit ;

Verdun, Stephane ;

Thouvenot, Benoit ;

Hilselberger, Benoit ;

Doncescu, Andrei ;

Lamant, Laurence ;

Lacroix-Triki, Magali ;

Favre, Gilles ;

Pradines, Anne .

ACTA DERMATO-VENEREOLOGICA, 2016, 96 (01) :29-34

[8] Final Version of 2009 AJCC Melanoma Staging and Classification [J].

Balch, Charles M. ;

Gershenwald, Jeffrey E. ;

Soong, Seng-jaw ;

Thompson, John F. ;

Atkins, Michael B. ;

Byrd, David R. ;

Buzaid, Antonio C. ;

Cochran, Alistair J. ;

Coit, Daniel G. ;

Ding, Shouluan ;

Eggermont, Alexander M. ;

Flaherty, Keith T. ;

Gimotty, Phyllis A. ;

Kirkwood, John M. ;

McMasters, Kelly M. ;

Mihm, Martin C., Jr. ;

Morton, Donald L. ;

Ross, Merrick I. ;

Sober, Arthur J. ;

Sondak, Vernon K. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (36) :6199-6206

[9] Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma [J].

Bald, Tobias ;

Quast, Thomas ;

Landsberg, Jennifer ;

Rogava, Meri ;

Glodde, Nicole ;

Lopez-Ramos, Dorys ;

Kohlmeyer, Judith ;

Riesenberg, Stefanie ;

van den Boorn-Konijnenberg, Debby ;

Hoemig-Hoelzel, Cornelia ;

Reuten, Raphael ;

Schadow, Benjamin ;

Weighardt, Heike ;

Wenzel, Daniela ;

Helfrich, Iris ;

Schadendorf, Dirk ;

Bloch, Wilhelm ;

Bianchi, Marco E. ;

Lugassy, Claire ;

Barnhill, Raymond L. ;

Koch, Manuel ;

Fleischmann, Bernd K. ;

Foerster, Irmgard ;

Kastenmueller, Wolfgang ;

Kolanus, Waldemar ;

Hoelzel, Michael ;

Gaffal, Evelyn ;

Tueting, Thomas .

NATURE, 2014, 507 (7490) :109-+

[10] BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: Implications for melanoma staging and adjuvant therapy [J].

Barbour, Andrew P. ;

Tang, Yue Hang ;

Armour, Nicola ;

Dutton-Regester, Ken ;

Krause, Lutz ;

Loffler, Kelly A. ;

Lambie, Duncan ;

Burmeister, Bryan ;

Thomas, Janine ;

Smithers, B. Mark ;

Hayward, Nicholas K. .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (15) :2668-2676

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