Characterization and Effect of Inflammatory Reaction of Duck-Feet Derived Collagen/Poly(lactic-co-glycolide)(PLGA) Hybrid Scaffold

被引：5

作者：

Kim, Soo Min ^{[1
,2
]}

Kim, Hye Min ^{[1
,2
]}

Kuk, Hyeon ^{[1
,2
]}

Kim, Eun Young ^{[1
,2
]}

Song, Jeong Eun ^{[1
,2
]}

Suh, Doug Sam ^{[3
]}

Park, Chan Hum ^{[4
]}

Khang, Gilson ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Polymer BIN Fus Res Ctr, Dept BIN Fus Tech, Jeonju 561756, Chonbuk, South Korea

[2] Chonbuk Natl Univ, Dept PolymerNano Sci Tech, Jeonju 561756, Chonbuk, South Korea

[3] Sewon Cellontech, Wooyoung Techno Ctr, Seoul 133831, South Korea

[4] Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, Chunchon 200702, Gangwon, South Korea

来源：

POLYMER-KOREA | 2015年 / 39卷 / 06期

关键词：

collagen; feet of duck; inflammatory reaction; scaffold; tissue engineering; MESENCHYMAL STEM-CELLS; VISCOELASTIC PROPERTIES; COLLAGEN; TISSUE; EXTRACTION; DESIGN;

D O I：

10.7317/pk.2015.39.6.837

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, hybrid scaffold composed of duck's feet extract (DC)/poly(lactic-co-glycolide) (PLGA) were fabricated to apply in tissue engineering. Characterizations such as compressive strength, SEM analysis and MTT were performed for the analysis of basic properties. RT-PCR, ROS and H&E staining were carried out for anti-inflammatory effect. DC/PLGA scaffolds have shown excellent mechanical properties and proliferation and can reduce inflammatory response. This study suggested that DC/PLGA scaffolds may serve as a potential cell delivery vehicle and a structural basis for tissue engineering.

引用

页码：837 / 845

页数：9

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