O-Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure-Function Study

被引：42

作者：

Capicciotti, Chantelle J. ^{[1
]}

Mancini, Ross S. ^{[1
]}

Turner, Tracey R. ^{[2
]}

Koyama, Toshie ^{[3
]}

Alteen, Matthew G. ^{[1
]}

Doshi, Malay ^{[1
]}

Inada, Takaaki ^{[3
]}

Acker, Jason P. ^{[2
]}

Ben, Robert N. ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Iorio Hall,10 Marie Curie, Ottawa, ON K1N 6N5, Canada

[2] Canadian Blood Serv, Ctr Innovat, 8249-114 St NW, Edmonton, AB T6G 2R8, Canada

[3] Natl Inst Adv Ind Sci & Technol, 1-2-1 Namiki, Tsukuba, Ibaraki 3058564, Japan

来源：

ACS OMEGA | 2016年 / 1卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

RED-BLOOD-CELLS; ANTIFREEZE GLYCOPROTEINS; NUCLEATING ACTIVITY; CLINICAL TOXICITY; LIVING CELLS; PROTEINS; CRYOPRESERVATION; MECHANISMS; SURVIVAL; PRESERVATION;

D O I：

10.1021/acsomega.6b00163

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of O-aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.

引用

页码：656 / 662

页数：7

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