The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome

被引：0
作者：
Yang, Jiejin [1 ]
Gong, Hao [2 ]
Liu, Wei [1 ]
Tao, Tao [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Internal Med, Div Endocrinol & Metab, Renji Hosp,Sch Med, Shanghai 200127, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Internal Med, Div Emergency, Renji Hosp,Sch Med, Shanghai 200127, Pudong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2013年 / 6卷 / 09期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
Polycystic ovary syndrome; peroxisome proliferator-activated receptor-gamma2; polymorphism; central obesity; hypertriglyceridemia; PPAR-GAMMA GENE; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; SUSCEPTIBILITY; POPULATION; CONSENSUS; MELLITUS; OBESITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The Pro12Ala polymorphism in the peroxisome Proliferator-activated receptor-gamma2 PPAR gamma 2) gene that account for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain elusive. Aim: To explore the association between PPAR gamma 2 gene pro12ala polymorphism and the metabolic characteristics in Chinese women with PCOS. Methods: PPAR gamma 2 gene Pro12Ala polymorphism was assayed by PCR/RFLP methods in 120 Chinese women with PCOS and 118 normal subjects. All subjects were examined by anthropometry, lipid profile, sex hormone, oral glucose tolerance tests and insulin tolerance tests. Results: In PCOS patients, women with the non-Pro/Pro genotypes of the PPAR gamma 2 gene Pro12Ala polymorphism showed statistically significantly higher fasting triglycerides (TG) levels and WHR value than those with the Pro/Pro genotype (P=.006 for both). There was no significant difference with PPAR gamma 2 Pro12Ala polymorphism distributions between Chinese Han women with PCOS and controls. Conclusion: PPAR gamma 2 gene Pro12Ala polymorphism was not supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of serum fasting TG levels and fat-deposition in abdomen, respectively.
引用
收藏
页码：1894 / 1902
页数：9
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