Radioresistant DNA synthesis in fibroblast cell lines derived from LEC strain rats

被引：13

作者：

Hayashi, M

Ishimori, K

Maeda, A

Watanabe, T

Arai, S

Okui, T

机构：

[1] HOKKAIDO UNIV,DEPT LAB ANIM SCI,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO INST PUBL HLTH,SAPPORO,HOKKAIDO 060,JAPAN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 352卷 / 1-2期

关键词：

DNA synthesis; LEC strain rat; radioresistance; X-irradiation;

D O I：

10.1016/0027-5107(96)00017-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Immortalized cell lines from LEC strain (LEC) rats by SV40 large T antigen were more sensitive to X-irradiation than the cell lines from WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a steep decline at low doses and a shallow decline at high doses. On the contrary, the dose-response curves for LEC-derived cell lines showed no steep component; they were almost identical to the shallow component of the curves for WKAH-derived cells.

引用

页码：117 / 121

页数：5

共 22 条

[1] COMPARATIVE HUMAN CELLULAR RADIOSENSITIVITY .1. THE EFFECT OF SV40 TRANSFORMATION AND IMMORTALIZATION ON THE GAMMA-IRRADIATION SURVIVAL OF SKIN DERIVED FIBROBLASTS FROM NORMAL INDIVIDUALS AND FROM ATAXIA-TELANGIECTASIA PATIENTS AND HETEROZYGOTES [J].