Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia

被引：26

作者：

Blijdorp, Karin ^{[1
,2
]}

van Waas, Marjolein ^{[1
]}

van der Lely, Aart-Jan ^{[2
]}

Pieters, Rob ^{[1
]}

van den Heuvel-Eibrink, Marry ^{[1
]}

Neggers, Sebastian ^{[1
,2
]}

机构：

[1] Erasmus MC Sophia Childrens Hosp Rotterdam, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr Rotterdam, Endocrinol Sect, Dept Med, NL-3000 CA Rotterdam, Netherlands

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 04期

关键词：

Childhood cancer; Acute myeloid leukemia; Chemotherapy; Stem cell transplantation; Endocrine sequelae; Metabolic syndrome; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; CELL TRANSPLANTATION; GROWTH; CANCER; CHEMOTHERAPY; FERTILITY; DENSITY; IMPACT; RISK;

D O I：

10.1016/j.leukres.2012.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with stem cell transplantation (SCT), after a median follow-up time of 20 years (range 9-31). In survivors treated with chemotherapy, no endocrinopathies or metabolic syndrome were present, although AMH and Inhibin B levels tended to be lower than in controls. In SCT survivors, pituitary deficiencies and metabolic syndrome were more frequent. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：367 / 371

页数：5

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