COVID-19 and pneumonia: a role for the uPA/uPAR system

被引：63
作者：
Alonzo, Daniele D. ' [1 ]
Fenza, Maria De [1 ]
Pavone, Vincenzo [1 ]
机构：
[1] Univ Naples Federico II, Dept Chem Sci, Complesso Univ Monte St Angelo,Via Cintia 46, I-80126 Naples, Italy
来源：
DRUG DISCOVERY TODAY | 2020年 / 25卷 / 08期
关键词：
PLASMINOGEN-ACTIVATOR RECEPTOR; FORMYL PEPTIDE RECEPTORS; RESPIRATORY-DISTRESS-SYNDROME; INHIBITS CELL-MIGRATION; UROKINASE RECEPTOR; SOLUBLE FORM; FPR1; CORONAVIRUSES; UPARANT; SUPAR;
D O I：
10.1016/j.drudis.2020.06.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Here, we highlight recent findings on the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system that suggest its potential role as a main orchestrator of fatal progression to pulmonary, kidney, and heart failure in patients with coronavirus. Patients with prolonged background inflammation can present aberrant inflammatory reactions, well recognized as the main factors that can result in death and probably sustained by a dysregulated uPA/uPAR system. SuPAR, the soluble form of uPAR, represents a biomarker of disease progression, and its levels correlate well with comorbidities associated with the death of patients with coronavirus. New drugs that regulate the uPA/uPAR system could help treat the severe complications of highly pathogenic human coronaviruses (hCoVs), including pandemic coronavirus 2019 (COVID-19).
引用
收藏
页码：1528 / 1534
页数：7
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