Robust and Adhesive Hydrogels from Cross-Linked Poly(ethylene glycol) and Silicate for Biomedical Use

被引：43
|
作者：
Wu, Chia-Jung [1 ]
Wilker, Jonathan J. [2 ]
Schmidt, Gudrun [1 ]
机构：
[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 01期
基金：
美国国家科学基金会;
关键词：
adhesives; elastomeric; hydrogels; polyethylene glycol; silicate nanoparticles; POLYMER-CLAY SOLUTIONS; ANGLE NEUTRON-SCATTERING; FIBROBLAST-GROWTH-FACTOR; NANOCOMPOSITE HYDROGELS; FLOW-BIREFRINGENCE; SKIN REGENERATION; WOUND CONTRACTION; SURGICAL TOOLBOX; CHITOSAN; RESPONSES;
D O I：
10.1002/mabi.201200362
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A systematic approach to develop robust and adhesive hydrogels by photopolymerizing poly(ethylene glycol) (PEG)-diacrylate and methoxy-PEG-acrylate in the presence of charged silicate nanoparticles (Laponite) is presented. PEG-diacrylate and silicate are used for covalent and physical cross-linking, thus providing the hydrogel with mechanical and adhesive strengths. Methoxy-PEG-acrylate is used as a softening agent. The resulting hydrogels can be extensively elongated and the hydrogels readily adhere to tissue even in the elongated state. These hydrogels may aid the development of adhesive tissue engineering matrixes, wound dressings, sealants, and the adhesive components of biomedical devices.
引用
收藏
页码：59 / 66
页数：8
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