Estrogenic endocrine disruptors: Molecular mechanisms of action

被引：195
作者：
Kiyama, Ryoiti [1 ]
Wada-Kiyama, Yuko [2 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Tsukuba, Ibaraki 3058566, Japan
[2] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan
来源：
ENVIRONMENT INTERNATIONAL | 2015年 / 83卷
关键词：
Endocrine disruptor; Estrogen action; Molecular mechanism; Techonology; Signal transduction; Toxicity pathway; BREAST-CANCER CELLS; ARYL-HYDROCARBON RECEPTOR; ACTIVATED PROTEIN-KINASE; POLYCYCLIC AROMATIC-HYDROCARBONS; NITRIC-OXIDE SYNTHASE; HYDROXYLATED POLYCHLORINATED-BIPHENYLS; DIESEL EXHAUST PARTICLES; REPORTER GENE ASSAYS; GROWTH-FACTOR-BETA; VITAMIN-D-RECEPTOR;
D O I：
10.1016/j.envint.2015.05.012
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action. First, estrogenic chemicals are categorized by structure as well as their applications, usage and effects. Second, estrogenic signaling is examined by the molecular mechanism based on the receptors, signaling pathways, crosstalk/bypassing and autocrine/paracrine/homeostatic networks involved in the signaling. Third, evaluation of estrogen action is discussed by focusing on the technologies and protocols of the assays for assessing estrogenicity. Understanding the molecular mechanisms of estrogen action is important to assess the action of endocrine disruptors and will be used for risk management based on pathway-based toxicity testing. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11 / 40
页数：30
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