Overnight transition from carbamazepine to oxcarbazepine in children and adolescents

被引:2
作者
Vaisleib, Inna I. [1 ]
Neft, Robyn A. [1 ]
机构
[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Div Child Neurol, Pittsburgh, PA 15213 USA
来源
PHARMACOTHERAPY | 2008年 / 28卷 / 10期
关键词
carbamazepine; oxcarbazepine; overnight transition; switch; conversion; epilepsy; seizures; antiepileptic drug; adverse effects;
D O I
10.1592/phco.28.10.1211
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Study Objective. To evaluate our clinical experience in pediatric patients who were rapidly switched from carbamazepine to oxcarbazepine at full therapeutic doses. Design. Retrospective medical record review. Setting. Children's hospital. Patients. Twenty six patients (mean age 9.8 yrs, range 5-21 yrs) with childhood epilepsy who were converted from carbamazepine to oxcarbazepine overnight between January 2003 and December 2005. Measurements and Main Results. Data collection included patient demographics, seizure type, epilepsy syndrome, seizure frequency, and adverse events. Dose conversion ratios for switching from carbamazepine to oxcarbazepine ranged from 1:1-1.5. The transition was well tolerated, with only three patients experiencing an adverse event (rash). Among the other 23 patients, seizure frequency decreased in 12 (52%), increased in two (9%), and remained unchanged in nine (39%). Conclusion. Overnight switching from carbamazepine to oxcarbazepine may be a useful option for pediatric patients who cannot tolerate or whose condition is unresponsive to carbamazepine.
引用
收藏
页码:1211 / 1214
页数:4
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