Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

被引：6

作者：

Pagire, Suvarna H. ^{[1
]}

Lee, Eunhye ^{[2
]}

Pagire, Haushabhau S. ^{[1
]}

Bae, Eun Jung ^{[1
]}

Ryu, Soo Jung ^{[1
]}

Lee, Dahye ^{[1
]}

Kim, Min Hee ^{[1
]}

Kim, Geum Ran ^{[3
]}

Hwang, Kyu-Seok ^{[3
]}

Ahn, Sukyung ^{[2
]}

Maeng, Jin Hee ^{[2
]}

Song, Jin Sook ^{[3
]}

Bae, Myung Ae ^{[3
]}

Lee, Don Hang ^{[2
]}

Ahn, Jin Hee ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea

[2] Utah Inha Drug Delivery Syst DDS & Adv Therapeut, Incheon 21988, South Korea

[3] Korea Res Inst Chem Technol, Drug Discovery Div, Daejeon 305600, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Glutamic acid derivatives; Ramalin; Antioxidant; NITRIC-OXIDE; RAMALIN;

D O I：

10.1016/j.bmcl.2017.11.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：529 / 532

页数：4

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