Membrane phosphoinositides and protein-membrane interactions

被引：4
|
作者：
Gokhale, Nikhil A. [1 ]
机构：
[1] NIEHS, Inositol Signaling Grp, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA
来源：
AMINO ACIDS | 2013年 / 45卷 / 04期
关键词：
Proteins; Phosphoinositides; Lipids; Protein-membrane interactions; Biochemistry; Signal transduction; PLASMA-MEMBRANE; PHOSPHORYLATION; SPECIFICITY; ENDOCYTOSIS; PI(4,5)P-2; MUTATION; RECEPTOR; AKT/PKB; DOMAINS; COMPLEX;
D O I：
10.1007/s00726-013-1512-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proteins with polybasic clusters bind to negatively charged phosphoinositides at the cell membrane. In this review, I have briefly discussed the types of phosphoinositides naturally found on membrane surfaces and how they recruit protein complexes for carrying out the process of signal transduction. A large number of researchers from around the world are now focusing their attention on protein-membrane binding, as these interactions have started to offer us a much better insight into the process of cell signaling. The main areas discussed in this brief review article include the phosphoinositide binding specificities of proteins and the role of their lipid binding in signaling processes downstream of membrane recruitment.
引用
收藏
页码：751 / 754
页数：4
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