The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

被引：117
作者：
Lupher, ML
Rao, N
Eck, MJ
Band, H
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[3] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0167-5699(99)01484-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.
引用
收藏
页码：375 / 382
页数：8
相关论文
共 62 条
[1]   TYROSINE-CONTAINING MOTIF THAT TRANSDUCES CELL ACTIVATION SIGNALS ALSO DETERMINES INTERNALIZATION AND ANTIGEN PRESENTATION VIA TYPE-III RECEPTORS FOR IGG [J].
AMIGORENA, S ;
SALAMERO, J ;
DAVOUST, J ;
FRIDMAN, WH ;
BONNEROT, C .
NATURE, 1992, 358 (6384) :337-341
[2]   syk protein tyrosine kinase regulates Fc receptor γ-chain-mediated transport to lysosomes [J].
Bonnerot, C ;
Briken, V ;
Brachet, V ;
Lankar, D ;
Cassard, S ;
Jabri, B ;
Amigorena, S .
EMBO JOURNAL, 1998, 17 (16) :4606-4616
[3]   All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral [J].
Bos, JL .
EMBO JOURNAL, 1998, 17 (23) :6776-6782
[4]   Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1 [J].
Boussiotis, VA ;
Freeman, GJ ;
Berezovskaya, A ;
Barber, DL ;
Nadler, LM .
SCIENCE, 1997, 278 (5335) :124-128
[5]   Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation [J].
Bustelo, XR ;
Crespo, P ;
LopezBarahona, M ;
Gutkind, JS ;
Barbacid, M .
ONCOGENE, 1997, 15 (21) :2511-2520
[6]   Lymphocyte signalling: A coordinating role for Vav? [J].
Cantrell, D .
CURRENT BIOLOGY, 1998, 8 (15) :R535-R538
[7]   ACTIVATION-INDUCED UBIQUITINATION OF THE T-CELL ANTIGEN RECEPTOR [J].
CENCIARELLI, C ;
HOU, D ;
HSU, KC ;
RELLAHAN, BL ;
WIEST, DL ;
SMITH, HT ;
FRIED, VA ;
WEISSMAN, AM .
SCIENCE, 1992, 257 (5071) :795-797
[8]   Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp [J].
Cohen, S ;
Dadi, H ;
Shaoul, E ;
Sharfe, N ;
Roifman, CM .
BLOOD, 1999, 93 (06) :2013-2024
[9]   Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product [J].
Deckert, M ;
TartareDeckert, S ;
Couture, C ;
Mustelin, T ;
Altman, A .
IMMUNITY, 1996, 5 (06) :591-604
[10]   Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases [J].
Deckert, M ;
Elly, C ;
Altman, A ;
Liu, YC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) :8867-8874
1234567