Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines

被引：4

作者：

McKelvey, Brittany A. ^{[1
,2
]}

Zeiger, Martha A. ^{[3
]}

Umbricht, Christopher B. ^{[1
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Dept Surg, Baltimore, MD USA

[2] Johns Hopkins Univ, Dept Mol Biol & Genet, Baltimore, MD USA

[3] NCI, Surg Oncol Program, NIH, Bethesda, MD 20892 USA

[4] Johns Hopkins Univ, Dept Oncol, Baltimore, MD USA

[5] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

来源：

MOLECULAR ONCOLOGY | 2020年 / 14卷 / 10期

关键词：

epigenetic regulation; monoallelic gene expression; monoallelic methylation; telomerase reverse transcriptase; TERTpromoter methylation; TERTpromoter mutation;

D O I：

10.1002/1878-0261.12798

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomerase regulation, includingTERTpromoter methylation, has been of long-standing interest to cancer biologists. Rowlandet al. have now vastly expanded their ongoing characterization ofTERTpromoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with activeTERTexpression in cancer cells. They further describe the interplay between activatingTERTpromoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization ofTERTpromoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on:

引用

页码：2355 / 2357

页数：3

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