Protein sensors for membrane sterols

被引：1395
作者：
Goldstein, JL [1 ]
DeBose-Boyd, RA [1 ]
Brown, MS [1 ]
机构：
[1] Univ Texas, Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA
来源：
CELL | 2006年 / 124卷 / 01期
关键词：
D O I：
10.1016/j.cell.2005.12.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and post-transcriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
引用
收藏
页码：35 / 46
页数：12
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