Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides

被引：11
作者：
Ajvazi, Njomza [1 ,2 ]
Stavber, Stojan [1 ,2 ,3 ]
机构：
[1] Jozef Stefan Inst, Dept Phys & Organ Chem, Jamova 39, Ljubljana 1000, Slovenia
[2] Jozef Stefan Int Postgrad Sch, Jamova 39, Ljubljana 1000, Slovenia
[3] Jozef Stefan Inst, Ctr Excellence Integrated Approaches Chem & Biol, Jamova 39, Ljubljana 1000, Slovenia
来源：
MOLECULES | 2016年 / 21卷 / 10期
关键词：
halohydrins; halogenation; water; tertiary alcohols; N-halosuccinimides; VIC-HALOHYDRINS; STEREOSELECTIVE-SYNTHESIS; ORGANIC-CHEMISTRY; WATER; OLEFINS; SOLVENT; FLUORINATION; BROMINATION; F-TEDA-BF4; CONVERSION;
D O I：
10.3390/molecules21101325
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The efficiency of direct conversion of tertiary alcohols bearing a beta-hydrogen atom to vicinal halohydrins-chlorohydrins and bromohydrins-under green reaction conditions was tested preliminarily on model tertiary benzyl alcohols. Tertiary alcohols were successfully directly halogenated to vicinal halohydrins with N-halosuccinimide in aqueous media. The efficiency of the reaction in water was significantly improved in the presence of sodium dodecyl sulphate as the surfactant.
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页数：9
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