Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells

被引：30

作者：

Yamashita, Takuya ^{[1
,2
]}

Nagano, Kazuya ^{[1
]}

Kanasaki, So-ichiro ^{[1
,2
]}

Maeda, Yuka ^{[1
,2
]}

Furuya, Takeshi ^{[1
,2
]}

Inoue, Masaki ^{[1
]}

Nabeshi, Hiromi ^{[2
]}

Yoshikawa, Tomoaki ^{[1
,2
]}

Yoshioka, Yasuo ^{[1
,2
,3
]}

Itoh, Norio ^{[2
]}

Abe, Yasuhiro ^{[1
]}

Kamada, Haruhiko ^{[1
,3
]}

Tsutsumi, Yasuo ^{[1
,2
,3
]}

Tsunoda, Shin-ichi ^{[1
,3
,4
]}

机构：

[1] Natl Inst Biomed Innovat, Lab Biopharmaceut Res, Osaka 5670085, Japan

[2] Osaka Univ, Lab Toxicol & Safety Sci, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Ctr Adv Med Engn & Informat, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Biomed Innovat, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 421卷 / 01期

基金：

日本学术振兴会;

关键词：

Malignant mesothelioma; Cisplatin susceptibility; Annexin A4; Biomarker; Proteomics; PERITONEAL MESOTHELIOMA; INTRAPERITONEAL CHEMOTHERAPY; ONCOLOGY-GROUP; IV; ASBESTOS; ASSOCIATION; EXPRESSION; SURVIVAL; EFFICACY; CANCER;

D O I：

10.1016/j.bbrc.2012.03.144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesothelioma is a highly malignant tumor with a poor prognosis and limited treatment options. Although cisplatin (CDDP) is an effective anticancer drug, its response rate is only 20%. Therefore, discovery of biomarkers is desirable to distinguish the CDDP-susceptible versus resistant cases. To this end, differential proteome analysis was performed to distinguish between mesothelioma cells of different CDDP susceptibilities, and this revealed that expression of annexin A4 (ANXA4) protein was higher in CDDP-resistant cells than in CDDP-susceptible cells. Furthermore, ANXA4 expression levels were higher in human clinical malignant mesothelioma tissues than in benign mesothelioma and normal mesothelial tissues. Finally, increased susceptibility was observed following gene knockdown of ANXA4 in mesothelioma cells, whereas the opposite effect was observed following transfection of an ANXA4 plasmid. These results suggest that ANXA4 has a regulatory function related to the cisplatin susceptibility of mesothelioma cells and that it could be a biomarker for CDDP susceptibility in pathological diagnoses. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：140 / 144

页数：5

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