Copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters

被引：2

作者：

Chen, Zhiwei ^{[1
,3
]}

Huang, Xiang ^{[2
,3
]}

Liao, Jian ^{[1
,2
,3
]}

Wang, Min ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TETRASUBSTITUTED GEM-DIFLUOROALKENES; STEREOSELECTIVE-SYNTHESIS; ALPHA-FLUOROALKENYLATION; HYDRODEFLUORINATION; FLUOROOLEFINS; BORYLATION; ACTIVATION;

D O I：

10.1039/d2qo01141g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters was developed. Under mild conditions, fluoroalkenylated products of cyclic imino esters were delivered in good yields with a broad substrate scope. A full-substituted carbon center along with a tetrasubstituted fluoroalkene was forged with good stereoselectivity. Late-stage functionalization of pharmaceuticals was also illustrated through this protocol with high enantioselectivities.

引用

页码：163 / 168

页数：6

共 36 条

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