Efficient Construction of Polycyclic Derivatives via a Highly Selective CuI-Catalyzed Domino Reductive-Aldol Cyclization

被引：64
作者：
Deschamp, Julia [1 ]
Riant, Olivier [1 ]
机构：
[1] Catholic Univ Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 06期
关键词：
ENANTIOSELECTIVE SYNTHESIS; BOND FORMATION; TANDEM; STRATEGY; KETONES; RHODIUM; GENERATION; HYDROGEN; MICHAEL; ESTERS;
D O I：
10.1021/ol802879f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A versatile methodology for the diastereo- and enantioselective domino reductive-aldol cyclizations is reported. By using a copper (I)/diphosphane ligand, various five- and six-membered rings were generated with good to excellent diastereo- and enantioselectivities (cis:trans up to 100:0 and ee up to 95%).
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页码：1217 / 1220
页数：4
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