Efficient Construction of Polycyclic Derivatives via a Highly Selective CuI-Catalyzed Domino Reductive-Aldol Cyclization

被引：64

作者：

Deschamp, Julia ^{[1
]}

Riant, Olivier ^{[1
]}

机构：

[1] Catholic Univ Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

关键词：

ENANTIOSELECTIVE SYNTHESIS; BOND FORMATION; TANDEM; STRATEGY; KETONES; RHODIUM; GENERATION; HYDROGEN; MICHAEL; ESTERS;

D O I：

10.1021/ol802879f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile methodology for the diastereo- and enantioselective domino reductive-aldol cyclizations is reported. By using a copper (I)/diphosphane ligand, various five- and six-membered rings were generated with good to excellent diastereo- and enantioselectivities (cis:trans up to 100:0 and ee up to 95%).

引用

页码：1217 / 1220

页数：4

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