Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality

被引：29

作者：

Milovanovic, Petar ^{[1
,2
]}

Busse, Bjoern ^{[1
,3
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Osteol & Biomech, Lottestr 55A, D-22529 Hamburg, Germany

[2] Univ Belgrade, Lab Anthropol & Skeletal Biol, Inst Anat, Fac Med, Belgrade, Serbia

[3] Univ Med Ctr Hamburg Eppendorf, FMTHH, Heisenberg Res Grp Biomed Sci, Hamburg, Germany

来源：

CURRENT OSTEOPOROSIS REPORTS | 2019年 / 17卷 / 03期

关键词：

Osteocyte distribution; Inter-site differences; Osteocyte lacunar number; Mechanical loading; Bone strength; Aging; Bone development; HUMAN PROXIMAL FEMUR; CORTICAL BONE; HIP FRACTURE; FEMORAL-NECK; MICRODAMAGE ACCUMULATION; BISPHOSPHONATE TREATMENT; BIOMECHANICAL PROPERTIES; MECHANICAL-PROPERTIES; POSTMENOPAUSAL WOMEN; TRABECULAR BONE;

D O I：

10.1007/s11914-019-00508-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewThis article provides a review on the variability of the osteocyte lacunar network in the human skeleton. It highlights characteristics of the osteocyte lacunar network in relation to different skeletal sites and fracture susceptibility.Recent FindingsApplication of 2D analyses (quantitative backscattered electron microscopy, histology, confocal laser scanning microscopy) and 3D reconstructions (microcomputed tomography and synchrotron radiation microcomputed tomography) provides extended high-resolution information on osteocyte lacunar properties in individuals of various age (fetal, children's growth, elderly), sex, and disease states with increased fracture risk.SummaryRecent findings on the distribution of osteocytes in the human skeleton are reviewed. Quantitative data highlighting the variability of the osteocyte lacunar network is presented with special emphasis on site specificity and maintenance of bone health. The causes and consequences of heterogeneous distribution of osteocyte lacunae both within specific regions of interest and on the skeletal level are reviewed and linked to differential bone quality factors and fracture susceptibility.

引用

页码：105 / 115

页数：11

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