Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection

被引：19

作者：

Byrne, Guerard W. ^{[1
,2
]}

Azimzadeh, Agnes M. ^{[3
,4
]}

Ezzelarab, Mohamed ^{[5
]}

Tazelaar, Henry D. ^{[6
]}

Ekser, Burcin ^{[5
]}

Pierson, Richard N. ^{[3
,4
]}

Robson, Simon C. ^{[7
]}

Cooper, David K. C. ^{[5
]}

McGregor, Christopher G. A. ^{[1
,2
]}

机构：

[1] UCL, Inst Cardiovasc Sci, London W1G 8PH, England

[2] Mayo Clin, Dept Surg, Rochester, MN USA

[3] Univ Maryland, Sch Med, Div Cardiothorac Surg, Baltimore, MD 21201 USA

[4] Baltimore VAMC, Baltimore, MD USA

[5] Univ Pittsburgh, Dept Surg, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA

[6] Mayo Clin, Dept Lab Med & Pathol, Scottsdale, AZ USA

[7] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

来源：

XENOTRANSPLANTATION | 2013年 / 20卷 / 05期

关键词：

cardiac transplantation; coagulation; complement activation; Gal epitope; orthotopic transplantation; xenotransplantation; PORCINE ENDOTHELIAL-CELLS; N-GLYCOLYLNEURAMINIC ACID; ORTHOTOPIC HEART-TRANSPLANTATION; TO-BABOON XENOTRANSPLANTATION; ACUTE VASCULAR REJECTION; EXPRESSING HUMAN THROMBOMODULIN; GENE-KNOCKOUT PIGS; HYPERACUTE REJECTION; MONOCLONAL-ANTIBODY; CYNOMOLGUS MONKEYS;

D O I：

10.1111/xen.12050

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The histopathology of cardiac xenograft rejection has evolved over the last 20yr with the development of new modalities for limiting antibody-mediated injury, advancing regimens for immune suppression, and an ever-widening variety of new donor genetics. These new technologies have helped us progress from what was once an overwhelming anti-Gal-mediated hyperacute rejection to a more protracted anti-Gal-mediated vascular rejection to what is now a more complex manifestation of non-Gal humoral rejection and coagulation dysregulation. This review summarizes the changing histopathology of Gal- and non-Gal-mediated cardiac xenograft rejection and discusses the contributions of immune-mediated injury, species-specific immune-independent factors, transplant and therapeutic procedures, and donor genetics to the overall mechanism(s) of cardiac xenograft rejection.

引用

页码：292 / 307

页数：16

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