Arsenic trioxide as a novel anti-glioma drug: a review

被引：49
作者：
Fang, Yi [1 ]
Zhang, Zhen [1 ]
机构：
[1] China Med Univ, Dept Ultrasound, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
来源：
CELLULAR & MOLECULAR BIOLOGY LETTERS | 2020年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Arsenic trioxide; Glioma; Anti-cancer mechanism; AUTOPHAGIC CELL-DEATH; PHASE-II TRIAL; ACUTE PROMYELOCYTIC LEUKEMIA; MALIGNANT GLIOMA-CELLS; TRANS-RETINOIC ACID; INDUCED APOPTOSIS; RADIATION-THERAPY; DOWN-REGULATION; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION;
D O I：
10.1186/s11658-020-00236-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. However, glioma cells and tissues from other sources show different responses to arsenic trioxide. Researchers are working to enhance its efficacy in anti-glioma treatments and reducing any adverse reactions. Here, we review recent research on the efficacy and mechanisms of action of arsenic trioxide in the treatment of gliomas to provide guidance for future studies.
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页数：13
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