Nonlinear Brillouin spectroscopy: what makes it a better tool for biological viscoelastic measurements

被引：23
作者：
Ballmann, Charles W. [1 ]
Meng, Zhaokai [1 ]
Yakovlev, Vladislav V. [1 ,2 ]
机构：
[1] Texas A&M Univ, College Stn, TX 77843 USA
[2] Zhejiang Univ, Hangzhou 310027, Zhejiang, Peoples R China
来源：
BIOMEDICAL OPTICS EXPRESS | 2019年 / 10卷 / 04期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
CHEMICAL-PROPERTIES; SCATTERING; BIOMECHANICS; TIME;
D O I：
10.1364/BOE.10.001750
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Brillouin spectroscopy is an emerging tool in biomedical imaging and sensing. It is capable of assessing the high-frequency viscoelastic longitudinal modulus with microscopic spatial resolution. Nonlinear Brillouin spectroscopy based on impulsive stimulated Brillouin scattering offers a number of significant advantages over conventional spontaneous and stimulated Brillouin scattering. In this report, we evaluate the accuracy of Brillouin shift measurements in spontaneous and nonlinear Brillouin microscopy by calculating the Allan variance for both CW excited spontaneous Brillouin measurements and nonlinear Brillouin scattering measurements made with both nanosecond and picosecond pulse excitation. We find that impulsive stimulated Brillouin spectroscopy is superior to spontaneous Brillouin spectroscopy in terms of the accuracy of such measurements and demonstrate its application for assessing tiny changes in Brillouin frequency shifts associated with low concentrations of biologically relevant solutions. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码：1750 / 1759
页数：10
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