Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease

被引：32

作者：

Segal, Jonathan P. ^{[1
,2
,3
]}

Mullish, Benjamin H. ^{[1
,2
,3
]}

Quraishi, Mohammed N. ^{[4
,5
]}

Iqbal, Tariq ^{[4
,5
]}

Marchesi, Julian R. ^{[3
,6
]}

Sokol, Harry ^{[7
,8
,9
,10
]}

机构：

[1] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept Gastroenterol, South Wharf Rd, London W2 1NY, England

[2] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept Hepatol, South Wharf Rd, London W2 1NY, England

[3] Imperial Coll London, Dept Metab Digest & Reprod, Div Digest Dis, London, England

[4] Univ Birmingham, Microbiome Treatment Ctr, Birmingham, W Midlands, England

[5] Univ Hosp Birmingham NHS Fdn Trust, Dept Gastroenterol, Birmingham, W Midlands, England

[6] Cardiff Univ, Sch Biosci, Cardiff, Wales

[7] Sorbonne Univ, St Antoine Hosp, AP HP,CRSA, INSERM,Ctr Rech St Antoine,Gastroenterol Dept, Paris, France

[8] INRA, UMR1319 Micalis, Jouy En Josas, France

[9] AgroParisTech, Jouy En Josas, France

[10] Paris Ctr Microbiome Med PaCeMM FHU, Paris, France

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2020年 / 13卷

关键词：

faecal microbiota transplantation; gastrointestinal disease; mechanistics; metabonomics; microbiota; CLOSTRIDIUM-DIFFICILE INFECTION; ACTIVE ULCERATIVE-COLITIS; REGULATORY T-CELLS; GUT MICROBIOTA; STRAIN TRACKING; RECURRENT; ACID; REMISSION; THERAPY; HEALTH;

D O I：

10.1177/1756284820946904

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/refractoryClostridioides difficileinfection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding of this may allow us to expose FMT's full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.

引用

页数：14