The topopyrones poison human DNA topoisomerases I and II

被引：17
|
作者：
Khan, Qasirn A. [1 ]
Elban, Mark A. [2 ,3 ]
Hecht, Sidney M. [1 ,2 ,3 ]
机构：
[1] Arizona State Univ, Biodesign Inst, Ctr BioEnerget, Tempe, AZ 85287 USA
[2] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
[3] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 39期
关键词：
D O I：
10.1021/ja805421b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The lopopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.
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收藏
页码：12888 / +
页数：3
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