Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

被引：100

作者：

Rinaldi, Sabina ^{[1
]}

Lise, Mauro ^{[2
]}

Clavel-Chapelon, Francoise ^{[3
,4
]}

Boutron-Ruault, Marie-Christine ^{[3
,4
]}

Guillas, Gwenaelle ^{[3
,4
]}

Overvad, Kim ^{[5
]}

Tjonneland, Anne ^{[6
]}

Halkjaer, Jytte ^{[6
]}

Lukanova, Annekatrin ^{[7
]}

Kaaks, Rudolf ^{[7
]}

Bergmann, Manuela M. ^{[8
]}

Boeing, Heiner ^{[8
]}

Trichopoulou, Antonia ^{[9
,10
]}

Zylis, Dimosthenis ^{[10
]}

Valanou, Elissavet ^{[10
]}

Palli, Domenico ^{[11
]}

Agnoli, Claudia ^{[12
]}

Tumino, Rosario ^{[13
,14
]}

Polidoro, Silvia ^{[15
]}

Mattiello, Amalia ^{[16
]}

Bueno-de-Mesquita, H. Bas ^{[17
,18
]}

Peeters, Petra H. ^{[19
,20
]}

Weiderpass, Elisabete ^{[21
,22
,23
,24
]}

Lund, Eiliv ^{[21
]}

Skeie, Guri ^{[21
]}

Rodriguez, Laudina ^{[25
]}

Travier, Noemie ^{[26
]}

Sanchez, Maria-Jose ^{[27
]}

Amiano, Pilar

Huerta, Jose-Maria ^{[28
]}

Ardanaz, Eva ^{[29
]}

Rasmuson, Torgny ^{[30
]}

Hallmans, Goeran ^{[31
]}

Almquist, Martin ^{[32
,33
]}

Manjer, Jonas ^{[33
]}

Tsilidis, Konstantinos K. ^{[34
,35
]}

Allen, Naomi E. ^{[34
]}

Khaw, Kay-Tee ^{[36
]}

Wareham, Nick ^{[37
]}

Byrnes, Graham ^{[1
]}

Romieu, Isabelle ^{[1
]}

Riboli, Elio ^{[20
]}

Franceschi, Silvia ^{[1
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon, France

[2] Aviano Canc Ctr, Epidemiol & Biostat Unit, I-33081 Aviano, Italy

[3] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat, U1018, F-94805 Villejuif, France

[4] Paris S Univ, UMRS Inserm 1018, Team 9, F-94805 Villejuif, France

[5] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[6] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[7] German Canc Res Ctr, Hormones & Canc Grp, Div Canc Epidemiol, Heidelberg, Germany

[8] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[9] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[10] Hellen Hlth Fdn, Athens, Greece

[11] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[12] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[13] Civile MP Arezzo Hosp, ASP 7, Canc Registry, Ragusa, Italy

[14] Civile MP Arezzo Hosp, ASP 7, Histopathol Unit, Ragusa, Italy

[15] Human Genet Fdn HuGeF, Lab Mol Epidemiol, Turin, Italy

[16] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[17] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[18] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[19] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[20] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London SW7 2AZ, England

[21] Univ Tromso, Dept Community Med, Tromso, Norway

[22] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[23] Canc Registry Norway, Dept Res, Oslo, Norway

[24] Samfundet Folkhalsan, Dept Genet Epidemiol, Helsinki, Finland

[25] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[26] Catalan Inst Oncol ICO, Bellvitge Biomed Res Inst IDIBELL, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[27] Andalusian Sch Publ Hlth, Granada, Spain

[28] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[29] Navarre Publ Hlth Inst, Pamplona, Spain

[30] Umea Univ, Dept Radiat Sci, Umea, Sweden

[31] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[32] Univ Lund Hosp, Dept Surg, S-22185 Lund, Sweden

[33] Malmo Univ Hosp, Malmo Diet & Canc Study, Malmo, Sweden

[34] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[35] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece

[36] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[37] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2012年 / 131卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

body size; differentiated thyroid carcinoma; EPIC; POOLED ANALYSIS; CANCER-RISK; MASS INDEX; ANTHROPOMETRIC FACTORS; STIMULATING HORMONE; PHYSICAL-ACTIVITY; FAT DISTRIBUTION; NEW-CALEDONIA; OBESITY; WEIGHT;

D O I：

10.1002/ijc.27601

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m2) (HR highest vs lowest quintile = 1.41, 95% CI: 1.031.94); height (HR = 1.61; 95% CI: 1.182.20); HR highest vs lowest tertile waist (HR = 1.34, 95% CI: 1.001.79) and waist-to-hip ratio (HR = 1.42, 95% CI: 1.051.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile = 3.03, 95% CI: 1.307.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC.

引用

页码：E1004 / E1014

页数：11

共 50 条

[1] Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can) [J].