Update in clinical allergy and immunology

被引：6
作者：
von Gunter, S. [2 ]
Marsland, B. J. [3 ]
von Garnier, C. [4 ]
Simon, D. [1 ]
机构：
[1] Univ Bern, Inselspital, Dept Dermatol, CH-3010 Bern, Switzerland
[2] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland
[3] Hosp Univ Vaudois, Dept Resp Med, Lausanne, Switzerland
[4] Univ Bern, Inselspital, Dept Resp Med, CH-3010 Bern, Switzerland
来源：
ALLERGY | 2012年 / 67卷 / 12期
基金：
瑞士国家科学基金会;
关键词：
asthma; atopic dermatitis; clinical immunology; eosinophils; innate immunity; THYMIC STROMAL LYMPHOPOIETIN; ANTIGEN-PRESENTING CELLS; GRAM-POSITIVE BACTERIA; ATOPIC-DERMATITIS; FILAGGRIN MUTATIONS; T-CELLS; SKIN BARRIER; CONTACT SENSITIZATION; MICROBIAL EXPOSURE; HYGIENE HYPOTHESIS;
D O I：
10.1111/all.12067
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as cellular mechanisms of disease, is discussed separately and in the context of atopic dermatitis, as an allergic model disease. Besides summarizing novel evidence, this update highlights current areas of uncertainties and debates that, as we hope, shall stimulate scientific discussions and research activities in the field.
引用
收藏
页码：1491 / 1500
页数：10
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