Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2

被引：226

作者：

Pankratz, Nathan ^{[1
]}

Beecham, Gary W. ^{[2
]}

DeStefano, Anita L. ^{[3
,4
]}

Dawson, Ted M. ^{[5
]}

Doheny, Kimberly F. ^{[5
]}

Factor, Stewart A. ^{[6
]}

Hamza, Taye H. ^{[7
]}

Hung, Albert Y. ^{[8
]}

Hyman, Bradley T. ^{[8
,9
]}

Ivinson, Adrian J. ^{[9
]}

Krainc, Dmitri ^{[8
]}

Latourelle, Jeanne C. ^{[3
]}

Clark, Lorraine N. ^{[10
]}

Marder, Karen ^{[10
]}

Martin, Eden R. ^{[2
]}

Mayeux, Richard ^{[10
]}

Ross, Owen A. ^{[11
]}

Scherzer, Clemens R. ^{[9
,12
,13
]}

Simon, David K. ^{[14
]}

Tanner, Caroline ^{[15
]}

Vance, Jeffery M. ^{[2
]}

Wszolek, Zbigniew K. ^{[11
]}

Zabetian, Cyrus P. ^{[16
,17
]}

Myers, Richard H. ^{[3
]}

Payami, Haydeh ^{[7
]}

Scott, William K. ^{[2
]}

Foroud, Tatiana ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[2] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[3] Boston Univ, Sch Med, Boston, MA 02118 USA

[4] Boston Univ, Sch Publ Hlth, Boston, MA USA

[5] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[6] Emory Univ, Atlanta, GA 30322 USA

[7] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Harvard Univ, Sch Med, Biomarker Program, Harvard NeuroDiscovery Ctr, Boston, MA USA

[10] Columbia Univ, Coll Phys & Surg, Sch Med, New York, NY USA

[11] Mayo Clin, Jacksonville, FL 32224 USA

[12] Partners Parkinson Ctr, Boston, MA USA

[13] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[14] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[15] Parkinsons Inst, Sunnyvale, CA USA

[16] VA Puget Sound Hlth Care Syst, Seattle, WA USA

[17] Univ Washington, Seattle, WA 98195 USA

来源：

ANNALS OF NEUROLOGY | 2012年 / 71卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; ALPHA-SYNUCLEIN; RISK-FACTORS; CALMODULIN; SNCA; SUSCEPTIBILITY; HAPLOTYPES; VARIANTS; SEQUENCE; GENETICS;

D O I：

10.1002/ana.22687

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility.

引用

页码：370 / 384

页数：15

共 25 条

[1] The Genetics of Parkinson Disease [J].

Bekris, Lynn M. ;

Mata, Ignacio F. ;

Zabetian, Cyrus P. .

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2010, 23 (04) :228-242

[2] Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death [J].

Bossers, Koen ;

Meerhoff, Gideon ;

Balesar, Rawien ;

van Dongen, Jeroen W. ;

Kruse, Chris G. ;

Swaab, Dick F. ;

Verhaagen, Joost .

BRAIN PATHOLOGY, 2009, 19 (01) :91-107

[3] Epidemiology of Parkinson's disease [J].

de Lau, Lonneke M. L. ;

Breteler, Monique M. B. .

LANCET NEUROLOGY, 2006, 5 (06) :525-535

[4] Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease [J].

Edwards, Todd L. ;

Scott, William K. ;

Almonte, Cherylyn ;

Burt, Amber ;

Powell, Eric H. ;

Beecham, Gary W. ;

Wang, Liyong ;

Zuchner, Stephan ;

Konidari, Ioanna ;

Wang, Gaofeng ;

Singer, Carlos ;

Nahab, Fatta ;

Scott, Burton ;

Stajich, Jeffrey M. ;

Pericak-Vance, Margaret ;

Haines, Jonathan ;

Vance, Jeffery M. ;

Martin, Eden R. .

ANNALS OF HUMAN GENETICS, 2010, 74 :97-109

[5] Highly parallel genomic assays [J].

Fan, Jian-Bing ;

Chee, Mark S. ;

Gunderson, Kevin L. .

NATURE REVIEWS GENETICS, 2006, 7 (08) :632-644

[6] Genome-wide genotyping in Parkinson's disease and neurologically normal controls:: first stage analysis and public release of data [J].

Fung, Hon-Chung ;

Scholz, Sonja ;

Matarin, Mar ;

Simon-Sanchez, Javier ;

Hernandez, Dena ;

Britton, Angela ;

Gibbs, J. Raphael ;

Langefeld, Carl ;

Stiegert, Matt L. ;

Schymick, Jennifer ;

Okun, Michael S. ;

Mandel, Ronald J. ;

Fernandez, Hubert H. ;

Foote, Kelly D. ;

Rodriguez, Ramon L. ;

Peckham, Elizabeth ;

De Vrieze, Fabienne Wavrant ;

Gwinn-Hardy, Katrina ;

Hardy, John A. ;

Singleton, Andrew .

LANCET NEUROLOGY, 2006, 5 (11) :911-916

[7] A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms [J].

Gao, Xiaoyi ;

Stamier, Joshua ;

Martin, Eden R. .

GENETIC EPIDEMIOLOGY, 2008, 32 (04) :361-369

[8] THE RELEVANCE OF THE LEWY BODY TO THE PATHOGENESIS OF IDIOPATHIC PARKINSONS-DISEASE [J].

GIBB, WRG ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (06) :745-752

[9] Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease [J].

Hamza, Taye H. ;

Zabetian, Cyrus P. ;

Tenesa, Albert ;

Laederach, Alain ;

Montimurro, Jennifer ;

Yearout, Dora ;

Kay, Denise M. ;

Doheny, Kimberly F. ;

Paschall, Justin ;

Pugh, Elizabeth ;

Kusel, Victoria I. ;

Collura, Randall ;

Roberts, John ;

Griffith, Alida ;

Samii, Ali ;

Scott, William K. ;

Nutt, John ;

Factor, Stewart A. ;

Payami, Haydeh .

NATURE GENETICS, 2010, 42 (09) :781-U75

[10] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

← 1 2 3 →