Enantioselective Hydrogenation of a-Substituted Acrylic Acids Catalyzed by Iridium Complexes with Chiral Spiro Aminophosphine Ligands

被引：80

作者：

Zhu, Shou-Fei ^{[1
,2
]}

Yu, Yan-Bo ^{[1
,2
]}

Li, Shen ^{[1
,2
]}

Wang, Li-Xin ^{[1
,2
]}

Zhou, Qi-Lin ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 35期

基金：

中国国家自然科学基金;

关键词：

asymmetric hydrogenation; carboxylic acids; homogeneous catalysis; iridium; N; P-ligands; ASYMMETRIC HYDROGENATION; CARBOXYLIC-ACIDS; DIPHOSPHINE LIGANDS; PERSPECTIVES; IMPACT;

D O I：

10.1002/anie.201204363

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly active: Iridium complexes with chiral spiro aminophosphine ligands were synthesized and applied as catalysts for the asymmetric hydrogenation of α-substituted acrylic acids (see scheme). The complexes were highly active catalysts, showing turnover frequencies of up to 6000 h -1, and catalyst loadings could be reduced to 0.01 mol %. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8872 / 8875

页数：4

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