N-Alkylation of benzimidazoles with ketonic Mannich bases and the reduction of the resulting 1-(3-oxopropyl)benzimidazoles

被引：6

作者：

Roman, Gheorghe ^{[1
]}

机构：

[1] Petru Poni Inst Macromol Chem, Iasi 700487, Romania

来源：

CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2012年 / 10卷 / 05期

关键词：

Benzimidazole; Mannich bases; N-alkylation; Reduction; DERIVATIVES; REACTIVITY; CHEMISTRY;

D O I：

10.2478/s11532-012-0062-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Benzimidazole, benzimidazoles diversely substituted at position 2, and 5,6-dimethylbenzimidazole have been alkylated at N (1) with ketonic Mannich bases derived from acetophenones, acetylnaphthalenes, 2-acetylthiophene and 1-tetralone to afford a series of novel 1-(3-oxopropyl)benzimidazoles. The reduction of these transamination products with NaBH4 in methanol produced the corresponding 1-(3-hydroxypropyl)benzimidazoles in excellent yields.

引用

页码：1516 / 1526

页数：11

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