Lipid research picks up speed on the slopes of Taos

被引:4
作者
Field, SJ
Lamia, KA
Rameh, LE
Cantley, LC
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Div Endocrinol, Boston, MA 02114 USA
[4] Boston Biomed Res Inst, Watertown, MA 02472 USA
关键词
D O I
10.1016/S1534-5807(02)00150-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The 2002 Keystone Symposium on "Regulation of Cellular Responses by Lipid Mediators" provided a lively and active forum to discuss research in lipid signaling. This meeting review can provide only a glimpse into the diversity of research presented. Here we have chosen to highlight a group of exciting presentations describing novel features of the temporal and spatial regulation of phosphoinositides and their downstream targets.
引用
收藏
页码:407 / 410
页数:4
相关论文
共 12 条
[1]   Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors [J].
Boronenkov, IV ;
Loijens, JC ;
Umeda, M ;
Anderson, RA .
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) :3547-3560
[2]   The lipid phosphatase SHIP2 controls insulin sensitivity [J].
Clément, S ;
Krause, U ;
Desmedt, F ;
Tanti, JF ;
Behrends, J ;
Pesesse, X ;
Sasaki, T ;
Penninger, J ;
Doherty, M ;
Malaisse, W ;
Dumont, JE ;
Le Marchand-Brustel, Y ;
Erneux, C ;
Hue, L ;
Schurmans, S .
NATURE, 2001, 409 (6816) :92-97
[3]   Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities [J].
Dowler, S ;
Currie, RA ;
Campbell, DG ;
Deak, M ;
Kular, G ;
Downes, CP ;
Alessi, DR .
BIOCHEMICAL JOURNAL, 2000, 351 (01) :19-31
[4]   The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin [J].
Dyson, JM ;
O'Malley, CJ ;
Becanovic, J ;
Munday, AD ;
Berndt, MC ;
Coghill, ID ;
Nandurkar, HH ;
Ooms, LM ;
Mitchell, CA .
JOURNAL OF CELL BIOLOGY, 2001, 155 (06) :1065-1079
[5]   Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α [J].
Fruman, DA ;
Mauvais-Jarvis, F ;
Pollard, DA ;
Yballe, CM ;
Brazil, D ;
Bronson, RT ;
Kahn, CR ;
Cantley, LC .
NATURE GENETICS, 2000, 26 (03) :379-382
[6]   Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease [J].
Kim, SA ;
Taylor, GS ;
Torgersen, KM ;
Dixon, JE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (06) :4526-4531
[7]   Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes [J].
Mauvais-Jarvis, F ;
Ueki, K ;
Fruman, DA ;
Hirshman, MF ;
Sakamoto, K ;
Goodyear, LJ ;
Iannacone, M ;
Accili, D ;
Cantley, LC ;
Kahn, CR .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (01) :141-149
[8]   A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control [J].
Odom, AR ;
Stahlberg, A ;
Wente, SR ;
York, JD .
SCIENCE, 2000, 287 (5460) :2026-2029
[9]   Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase [J].
Ueki, K ;
Yballe, CM ;
Brachmann, SM ;
Vicent, D ;
Watt, JM ;
Kahn, CR ;
Cantley, LC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :419-424
[10]   P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac [J].
Welch, HCE ;
Coadwell, WJ ;
Ellson, CD ;
Ferguson, GJ ;
Andrews, SR ;
Erdjument-Bromage, H ;
Tempst, P ;
Hawkins, PT ;
Stephens, LR .
CELL, 2002, 108 (06) :809-821