Identification of the chondrogenic pathway in the mandibular condylar cartilage

被引：4

作者：

Song, Yang ^{[1
]}

Wu, Charlene ^{[1
]}

Wong, Ricky Wing Kit ^{[1
]}

Rabie, A. Bakr M. ^{[1
]}

机构：

[1] Univ Hong Kong, Fac Dent, Dept Orthodont, Hong Kong, Hong Kong, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Mechanical; Stress; Cartilage; Mustang; CryAB; Noggin; NOV; CHAD; Microarray; Real time RT-PCR; condyles; ALPHA-B-CRYSTALLIN; OSTEOBLAST DIFFERENTIATION; GLENOID FOSSA; GROWTH-PLATE; CCN FAMILY; PROTEIN; EXPRESSION; CHONDROADHERIN; NOV/CCN3; NOGGIN;

D O I：

10.2741/3352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To identify genetic expression of mandibular condylar cartilage during natural growth and under mechanical strain as a result of mandibular advancement. One hundred and forty four 35 days old female Sprague-Dawley rats were sacrificed on 8 different experimental days. Total RNA was extracted for oligonucleotide microarray gene chips containing 15,923 transcripts. Sixteen genes representing the chondrogenesis pathway were identified. Five of them were novel and have never been identified in mandibular condyles before. Quantitative analysis using real-time PCR revealed that these genes were involved in different stages in chondrogenesis and played an important role in condylar growth.

引用

页码：1932 / U3857

页数：8

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