Microfluidic devices powered by integrated elasto-magnetic pumps

被引:12
作者
Binsley, Jacob L. [1 ]
Martin, Elizabeth L. [1 ]
Myers, Thomas O. [2 ]
Pagliara, Stefano [3 ]
Ogrin, Feodor Y. [1 ]
机构
[1] Univ Exeter, Dept Phys & Astron, Phys Bldg,Stocker Rd, Exeter EX4 4QL, Devon, England
[2] Platform Kinet Ltd, Wharfebank Mills LS21 3JP, Otley, England
[3] Univ Exeter, Living Syst Inst, Dept Biosci, Stocker Rd, Exeter EX4 4QD, Devon, England
基金
英国工程与自然科学研究理事会; 英国惠康基金; 欧盟地平线“2020”;
关键词
ON-A-CHIP; MICROPUMPS; SYSTEMS; MICROSWIMMERS; PROPULSION; PARTICLES; SWIMMER; POCT;
D O I
10.1039/d0lc00935k
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We show how an asymmetric elasto-magnetic system provides a novel integrated pumping solution for lab-on-a-chip and point of care devices. This monolithic pumping solution, inspired by Purcell's 3-link swimmer, is integrated within a simple microfluidic device, bypassing the requirement of external connections. We experimentally prove that this system can provide tuneable fluid flow with a flow rate of up to 600 mu L h(-1). This fluid flow is achieved by actuating the pump using a weak, uniform, uniaxial, oscillating magnetic field, with field amplitudes in the range of 3-6 mT. Crucially, the fluid flow can be reversed by adjusting the driving frequency. We experimentally prove that this device can successfully operate on fluids with a range of viscosities, where pumping at higher viscosity correlates with a decreasing optimal driving frequency. The fluid flow produced by this device is understood here by examining the non-reciprocal motion of the elasto-magnetic component. This device has the capability to replace external pumping systems with a simple, integrated, lab-on-a-chip component.
引用
收藏
页码:4285 / 4295
页数:11
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