Tissue Engineering and Regenerative Medicine: Past, Present, and Future

被引：105

作者：

Salgado, Antonio J. ^{[1
,2
]}

Oliveira, Joaquim M. ^{[2
,3
]}

Martins, Albino ^{[2
,3
]}

Teixeira, Fabio G. ^{[1
,2
]}

Silva, Nuno A. ^{[1
,2
]}

Neves, Nuno M. ^{[2
,3
]}

Sousa, Nuno ^{[1
,2
]}

Reis, Rui L. ^{[2
,3
]}

机构：

[1] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, Braga, Portugal

[2] ICVS 3Bs, PT Govt Associated Lab, Braga, Portugal

[3] Univ Minho, Res Grp Biomat Biodegradables & Biomimet 3Bs, Headquarters European Inst Excellence Tissue Engn, Taipas, Guimaraes, Portugal

来源：

TISSUE ENGINEERING OF THE PERIPHERAL NERVE: STEM CELLS AND REGENERATION PROMOTING FACTORS | 2013年 / 108卷

关键词：

MESENCHYMAL STEM-CELLS; FIBER-MESH SCAFFOLDS; MARROW STROMAL CELLS; SPINAL-CORD-INJURY; POLYCAPROLACTONE NANOFIBER MESHES; PERIPHERAL-NERVE REGENERATION; OLFACTORY ENSHEATHING CELLS; STARCH-BASED SCAFFOLDS; GUM-BASED HYDROGELS; INTERVERTEBRAL DISC;

D O I：

10.1016/B978-0-12-410499-0.00001-0

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Tissue and organ repair still represents a clinical challenge. Tissue engineering and regenerative medicine (TERM) is an emerging field focused on the development of alternative therapies for tissue/organ repair. This highly multidisciplinary field, in which bioengineering and medicine merge, is based on integrative approaches using scaffolds, cell populations from different sources, growth factors, nanomedicine, gene therapy, and other techniques to overcome the limitations-that currently exist in the clinics. Indeed, its overall objective is to induce the formation of new functional tissues, rather than just implanting spare parts. This chapter aims at introducing the reader to the concepts and techniques of TERM. It begins by explaining how TERM have evolved and merged into TERM, followed by a short overview of some of its key aspects such as the combinations of scaffolds with cells and nanomedicine, scaffold processing, and new paradigms of the use of stem cells for tissue repair/regeneration, which ultimately could represent the future of new therapeutic approaches specifically aimed at clinical applications.

引用

页码：1 / 33

页数：33

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[1] Collagens -: major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair [J].