K2CO3-mediated regioselective synthesis of isoxazoles and pyrazolines

被引：47

作者：

Kidwai, M ^{[1
]}

Kukreja, S ^{[1
]}

Thakur, R ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 02期

关键词：

Michael addition; regioselectivity; chalcones; solid support;

D O I：

10.2174/157017806775224170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,5-Diarylisoxazoles and 1,3,5-triarylpyrazolines are synthesized via Michael addition of "hydroxylamine hydrochloride, phenylhydrazine" respectively over chalcones followed by cyclization using K2CO3 as solid support. Reactions are shown to be highly regioselective regardless of the nature of the substituent in the Substrates and afforded single isoxazole and pyrazoline isomer in excellent yields.

引用

页码：135 / 139

页数：5

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